Our research focuses on transport proteins and ion channels that play key roles in vital physiological processes in the human body and represent attractive targets for the development of therapeutic applications. Transporters are gatekeepers in the membranes of cells and organelles and their dysfunction contributes to the pathogenesis of major human diseases such as diabetes, hypertension, cardiovascular diseases, cancer, preeclampsia and neurodegenerative diseases, as well as drug resistance. Determination of the structure, function and transport mechanisms of transporters, together with computational modelling and docking, provides the foundation for ligand-based drug design. Current projects are done in collaboration with chemistry collaborators Profs. Jean-Louis Reymond and Martin Lochner from the DCB, University of Bern, to generate hit and lead compounds as novel modulators of medically important transporters.