| 8:30 |
Matthias A. Hediger
- Introduction |
| Session I
|
Principles
of transmembrane and transcellular drug movement.
- Chair, Ernest Wright |
| 8:40 |
Anna Seelig -
(Biozentrum Basel) "Molecular
parameters governing passive diffusion through membranes" |
| 9:20 |
Barry Hirst - (University
of Newcastle, UK) "Paracellular Pathway" |
| BREAK
- 10:00 - 10:20 (Coffee) |
| 10:20 |
Ernest Wright
- (UCLA) "Carriers" |
| 11:00 |
David Clarke
- (University of Alberta) "Drug Transport by the Human
Multidrug Resistance P-glycoprotein" |
| 11:40
| Chris Cheeseman -
(University of Toronto)
"The use of vascular perfusion of the small intestine for assessing
absorption pathways" |
| Afternoon
LUNCH - 12:30 - 1:30 p.m. |
| Session II
|
Intestinal
transporters -
Chair, Frederick Leibach |
| 1:30 |
J.D. Young -
(University of Alberta) "Molecular
mechanisms of nucleoside and nucleoside drug transport" |
| 2:10 |
Frederick Leibach -
(Medical College of Georgia)
"Peptide transport" |
| 2:50 |
Hannelore Daniel -
(University of Giessen) "PEPT1 and PEPT2 transport functions
when expressed in yeast, insect and mammalian cells." |
| BREAK
- 3:30 - 3:50 (Coffee) |
| 3:50 |
Gordon Amidon
- (University of Michigan)
"Designing drugs for hPepT1 transport" |
| 4:30 |
P.A. Dawson -
(Wake Forest University) "Intestinal Bile Acid Transport: New
Molecules and Mechanisms" |
| 5:10 |
Akira Tsuji -
(Kanazawa University) "Transporter-mediated absorption and secretion
of drugs" |
| BREAK
- 5:50 - 6:10 (refreshments) |
| Session III
|
DISCUSSION
- 6:10 - 7:10 |
| |
"Intestinal
transporters and drug thrapy: What are the opportunities?" Chair
- Gordon Amidon (University of Michigan) |
| |
Discussants: David Clarke, Hannelore Daniel , P.A.
Dawson, Barry Hirst, Frederick Leibach ,Anna
Seelig, Akira Tsuji ,Ernest Wright, J.D. Young
, Chris Cheeseman
|
| Evening
- DINNER 7:15 - 8:30 p.m. |
| |
Poster Session
8:30 - 10:00 p.m. (posters to be displayed during the
entire meeting) |
| Session IV |
Kidney
drug transport and targeting
- Chair, Heini Murer |
| 8:15 am |
K.J. Ullrich -
(Max Planck Institute for Biophysiks) "Drug transport by the
kidney" |
| 8:40 am |
Hitoshi Endou -
(Kyorin University, Tokyo) "Role of the organic anion transporter
superfamily in renal drug transport" |
| 9:20 am |
Gerhard Burckhardt - (University
of Gottingen) "Renal organic anion transporters" |
| BREAK - 10:00
- 10:20 (Coffee) |
| 10:20 am |
Herman Koepsell -
(University of Wurzburg) "Organic cation transporters" |
| 11:00 am |
Chairat Shayakul -
(Siriraj Hospital, Bangkok) "Renal dicarboxylate transport potential
role in renal metabolism and pathogenesis of idiopathic hypocitraturia" |
| 11:40 am |
David Smith - (University
of Michigan) "Transport of ACE Inhibitors in kidney and intestine" |
| Session
IV A |
Discussion:
"Renal handling of drugs and targeting specific renal transporters",
Chair - Heini Murer (University of Zurich) |
| 12:20
pm |
Discussants:
Karl Ullrich, Hitoshi Endou, Gerhard Burkhardt, Herman Koepsell, Chairat
Shayakul and David Smith. |
|
Afternoon
|
| 12:50 pm |
Afternoon Tour:
Brissago Inseln / Villa Taranto |
| |
Pick
up bag lunch and walk down to the Ascona Harbor. Departure of cruise
boat at 1:55 pm. Enjoy the horticultural garden on the beautiful Brissago
Island. Return by Cruise boat at 4:35pm. Bus from Ascona Harbor to Monte
Verita. |
|
Evening - DINNER 6:00
|
| Session V |
Kidney drug
transport and targeting
- Chair, Hitochi Endou |
| 7:30 pm |
Jurg Biber -
(University of Zurich) "Phosphate transport and regulation" |
| 8:10 pm |
Yoshikatsu Kanai -
(Kyorin University) "Amino acid transporters in kidney, liver
and blood brain barrier" |
| 8:50 pm |
Francois Verrey -
(University of Zurich) "Amino acid transport by heterodimers
of 4F2 permease family" |
| BREAK - 9:30
(Refreshments) |
| Session V A |
DISCUSSION |
|
"Renal handling
of drugs and targeting specific renal transporters" -
Chair, Francois Verrey |
| 9:50
pm |
Discussants: Jurg
Biber and Yoshikatsu Kanai (30 minutes) |
| Session VII |
Transport
in Liver - Chair,
Peter Meier |
| 8:15 am |
Peter Meier -
(University of Zurich) "Overview" |
| 8:55 am |
Bruno Hagenbuch -
(University of Zurich) "Bile acid transport and organic anions" |
| 9:35 am |
Dietrich Keppler -
(Deutsches Krebsforschungszentrum) "The apical conjugate export
pump MRP2" |
| BREAK
- 10:15 (Coffee) |
| 10:30 |
Sander Smith -
(Academic Medical Center, Dept. of Gastrointestinal and Liver Diseases) "The
human MDR3 P-glycoprotein is involved in the transport of cytotoxic
drugs in vitro" |
| 11:10 am |
Ned Ballatori -
(University of Rochester) "Transport of metal ions and glutathione-mercaptides" |
| Session
VIII |
DISCUSSION: "Drug
transport and metabolism in the liver: What are the opportunities?"
Chair - Peter Meier |
| 11:50
am |
Discussants:
Bruno Hagenbuch, Dietrich Keppler, Sanders Smith and Ned Ballatori. |
| 12:30 pm |
Solar
Eclipse Viewing |
| Afternoon - LUNCH
- 12:40 |
| Session IX |
Blood-Brain
Barrier - Chair, Keith Horspool (AstraZeneca) |
| 2:00 pm |
Jorg Huwyler -
(Hoffmann-LaRoche) "The blood brain barrier: anatomy and brain
drug delivery." |
| 2:40 pm |
Yuchi Sugiyama
- (University of Tokyo)
"Characterization of tramsporters involved in efflux of compounds across
the blood-brain barrier and blood-CSF barrier" |
| BREAK
- 3:20 |
| 3:35 pm |
Jiunn Lin - (Merck
Research Laboratory) "Role of P-glycoprotein in brain uptake
drugs" |
| 4:15 pm |
Olaf van Tellingen -
(Netherlands Cancer Institute) "Use of knock-out mice to define
the role of transporters in blood brain barrier transport" |
| Session X |
DISCUSSION: "Transport
of drugs across the Blood-Brain Barrier: Opportunities and limitations"
Chair - Keith Horspool |
| 5:00
pm |
Discussants:
Jorg Huwyler, Jiunn Lin, Yuchi Sugiyama , Olaf van
Tellingen (40 minutes) |
| Special
DINNER - Hotel Ascona 6:30 - 9:00 |
| 6:30
pm |
The Hotel can be
reached through a short walk from the Monte Verita Center. There will
be a special music program (Canzoni Ticinesi). |
| Session XI |
New developments
in drug delivery and targeting - Chair, Soren-Peter
Olesen |
| 8:15 am |
Balazs Sarkadi - "Fluorescence
detection to monitor transporter activity during high throughput screens" |
| 8:55 am |
Soren-Peter Olesen -
(NeuroSearch, Copenhagen) - "NeuroPatch - A fully automated
patch-clamp technique used for drug screening" |
| Session XII |
Novel opportunities
in transporter research - Chair,
Seth Alper |
| 9:35 am |
Seth Alper -
(Harvard Medical School) - "Gene therapy in membrane transport
disease" |
| BREAK
- 10:15 (Coffee) |
| 10:30 am |
Imelda Lambkin -
(Elan Corporation) - "A Systemic Approach to Oral Protein
& Peptide Delivery" |
| 11:10 am |
Davide Trotti
- (Harvard Medical
School) - "Glutamate transporters and motor neuron disease" |
| 12:10 pm |
Vadivel Ganapathy -
(Medical College of Gerogia) - "The organic cation/carnitine
transporter OCTN2: a potential candidate for drug delivery" |
| 12:40 pm |
Xing-Zhen Chen
- (Harvard Medical
School) - "New insights into the function of Polycystic Kidney
Disease proteins" |
|
Afternoon - LUNCH - 1:10 p.m.
|
| Session XIII |
Pharmacogenomics
- Chair, Wolfgang Sadee |
| 2:10 pm |
Wolfgang Sadee
- (Univ. of Cal., San
Francisco) - "Pharmacogenetics/genomics relevant to drug
transporters" |
| 2:50 pm |
Kenneth S. Lown -
(University of Michigan Medical Center) - "The basis and
consequences of variable MDR1" |
| 3:30 pm |
Cheni Kwok - (Smith
Kline Beecham) "Genetic Approaches to the understanding of variability
in Drug Transporters" |
| 4:10 pm |
Closing
Remarks - Matthias Hediger |
|
Departure: ~ 4:20 PM
|
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