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Matthias A Hediger
University of Bern
Bern, Switzerland |
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Robert Burrier
Invitrogen
Grand Island, NY, USA
Ken-ichi Inui
Kyoto University
Kyoto, Japan
Bruno Stieger
University of Zurich
Zurich, Switzerland
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BioMedical Transporters 2007 - Membrane Transporters in Disease and Drug Development
:
August 12-16, 2007
Kursaal Congress Center, Bern, Switzerland
Organizer: Matthias
Hediger (Institute of Biochemistry and Molecular Medicine, University of Bern, Switzerland)
Co-Organizers:
Robert Burrier (Invitrogen, NY, USA)
Ken-ichi Inui (Kyoto University, Japan), Bruno Stieger (University of Zürich, Switzerland)
| SUNDAY |
| 4:00 pm - 8:00 pm |
Registration |
|
|
Reception |
| 7:45 pm - 8:00 pm |
Opening Remarks: Matthias Hediger, Conference Organizer |
| 8:00 pm - 9:00 pm |
Keynote Speaker: Andreas Engel (University of Basel, Switzerland)
“Transport of water, solutes and signals across cell membranes”
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|
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| MONDAY |
| 8:30 am - 12:00 pm |
ABC transporters: importance in diseases and drug delivery |
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Chair: Robert Tampé (Johann Wolfgang Goethe-Universität Frankfurt am Main, Germany) |
| |
|
| 8:30 am - 9:00 am |
Bruno Stieger (University of Zürich, Switzerland)
“Overview on ABC-transporters”
|
| 9:00 am - 9:30 am |
Scott W. Altmann (Schering-Plough Research Institute, Kenilworth, NJ, USA)
"Ezetimibe inhibition of intestinal NPC1L1 for the treatment of hypercholesterolemia" |
| 9:30 am - 10:00 am |
Christiane Albrecht (University of Bern, Switzerland)
"ABCA1, cholesterol transport and bleeding disorders"
|
| 10:00 am - 10:30 am |
Coffee Break
|
| 10:30 am - 11:00 am |
Robert Tampé (Johann Wolfgang Goethe-Universität Frankfurt am Main, Germany)
"ABC transporters in adaptive immunity"
|
| 11:00 am - 11:30 am |
Michael M. Gottesman (NCI, NIH, Bethesda, MD, USA)
"Learning new tricks from an old transporter" |
| 11:30 pm - 12:00 pm |
Anne H. Dantzig (Lilly Research Laboratories, Indianapolis, IN, USA)
"Identification of specific inhibitors of P-glycoprotein and MRPs" |
|
12:00 pm - 1:00 pm |
Lunch |
|
| |
| 1:00 pm - 5:00 pm |
Plasma membrane transporters:
importance in diseases, drug development and drug toxicity |
| |
Chair:
Ken-ichi Inui (Kyoto University, Japan) & Michael F. Romero (Mayo Clinic College of Medicine Rochester, MN, USA)
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| |
|
|
1:00 pm - 1:30 pm |
Kerry J. Koller (Xenoport, Santa Clara, CA, USA)
“Altering the active transport of drugs to improve pharmacokinetic properties”
|
| 1:30 pm - 2:00 pm |
Frans G. M. Russel (Radboud University Nijmegen Medical Centre, Netherlands)
“ABC transporters in renal drug excretion and acute kidney injury”
|
| 2:00 pm - 2:30 pm |
David K. Donald (AstraZeneca R&D Charnwood, UK)
“Monocarboxylate transporter MCT1 as a target for immunosuppression”
|
| 2:30 pm - 3:00 pm |
Coffee Break |
| 3:00 pm - 3:30 pm |
Ken-ichi Inui (Kyoto University Hospital, Japan)
"Molecular characterization of H+/organic cation antiporters (MATEs)" |
| 3:30 pm - 4:00 pm |
Taku Hirata (Kyorin University, Tokyo, Japan)
"Elucidation of function of an orphan transporter from SLC22 organic cation/anion/zwitterion transporter family by metabolome analysis" |
| 4:00 pm - 4:30 pm |
I. David Goldman(Albert Einstein College of Medicine, Bronx, NY, USA)
"Cloning and charaterization of a proton-coupled folate transporter, PCFT, and the molecular basis of hereditary folate malabsorption" |
| 4:30 pm - 5:00 pm |
Michael F. Romero (Mayo Clinic College of Medicine Rochester, MN, USA)
"NBCel, the molecular basis of proximal renal tubular acidosis and glaucoma - the kidney, flies and fish & back again" |
|
Evening |
Enjoy the beautiful "Old City" of Bern (no planned events) |
|
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| TUESDAY |
| 8:00 am - 10:00 am |
Intracellular membrane transporters: importance in diseases, drug development and drug toxicity |
| |
Chair:
Jashvant Unadkat (University of Washington, Seattle, WA, USA) |
| |
|
|
8:00 am - 8:30 am |
Ferdinando Palmieri (University of Bari, Italy)
“Mitochondrial transporters in health and diseases” |
|
8:30 am - 9:00 am |
Edmund R.S. Kunji (MRC Dunn Human Nutrition Unit, Cambridge, UK)
"Substrate recognition and transport mechanism of mitochondrial carriers" |
|
9:00 am - 9:30 am |
John D. Schuetz (St. Jude Children's Research Hospital Memphis, TN, USA)
"Role of the mitochondrial porphyrin transporter ABCB6 in porphyrin homeostasis" |
|
9:30 am - 10:00 am |
Jashvant D. Unadkat (University of Washington, Seattle, WA, USA)
"Mitochondrial and plasma membrane nucleoside transporters: role in drug toxicity" |
|
10:30 am - 3:30 pm |
Special Excursion to Schilthorn – Enjoy scenic views of the Alps (Includes lunch at revolving restaurant) |
| 5:00 pm - 7:00 pm |
"Apéro" Poster Session |
| |
Chair:
Christopher Landowski (University of Bern, Switzerland) |
| 7:00 pm - 9:00 pm |
Structure of transporters |
| |
Chair:
Michael F. Romero (Mayo Clinic College of Medicine, Rochester, MN , USA) |
|
7:00 pm - 7:15 pm |
Poster Awards – Presentation of awards for the top three posters
|
|
7:15 pm - 7:45 pm |
Satinder K. Singh (Oregon Health & Science University, Portland, OR, USA)
"Mechanism of inhibition in a neurotransmitter sodium symporter"
|
|
7:45 pm - 8:15 pm |
Olga Boudker (Weill Medical College of Cornell University, NY, NY, USA)
"Structure and ion binding to a Na+/Asp cotransporter & implications for other membrane transporters" |
|
8:15 pm - 8:45 pm |
Michael E. Maguire (Case Western Reserve University, Cleveland, OH, USA)
"Structure and function of Mg2+ transporters – CorA and beyond" |
|
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| WEDNESDAY |
| 9:00 am - 12:30 pm |
Drug transport across barriers |
|
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Chair:
Keith Hoffmaster (Pfizer, Cambridge, MA, USA) |
| |
|
|
9:00 am - 9:30 am |
Matthias A. Hediger (University of Bern, Bern, Switzerland)
"Nutrient transporters across epithelial barriers: Potential therapeutic applications"
|
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9:30 am - 10:00 am |
David J. Begley (Kings College, London, UK)
"Delivery of drugs across the blood-brain barrier: Questions that need addressing"
|
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10:00 am - 10:30 am |
Reina Bendayan (University of Toronto, Canada)
"Drug transporter interactions in the brain: Relevance to HIV-1 infection"
|
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10:30 am - 11:00 am |
Coffee Break
|
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11:00 am - 11:30 am |
Britta Engelhardt (University of Bern, Switzerland)
"Molecular mechanisms involved in immune cell migration across the blood-brain barrier during health and disease"
|
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11:30 am - 12:00 pm |
Wolfgang Löscher (University of Veterinary Medicine Hannover, Germany)
"The role of P-gp in CNS disorders"
|
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12:00 pm - 12:30 pm |
Vadivel Ganapathy (Medical College of Georgia, Augusta, GA, USA)
"Placental transporters: Role in fetal development, drug delivery and toxicity" |
|
12:30 pm - 1:30 pm |
Lunch |
|
| |
| 1:30 pm - 4:00 pm |
Regulation of membrane transporters and pharmaceutical implications |
|
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Chair: Bruno Stieger (University of Zürich, Switzerland) & Gerd Kullak-Ublick (University Hospital Zürich, Switzerland) |
| |
|
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1:30 pm - 2:00 pm |
Gerd Kullak-Ublick (University Hospital Zürich, Switzerland)
"Regulation of drug and bile acid transporters in liver and intestine" |
|
2:00 pm - 2:30 pm |
Olivier Staub (University of Lausanne, Switzerland)
"The role of ubiquitylation and deubiquitylation in the control of transepithelial Na+ transport" |
|
2:30 pm - 3:00 pm
|
Coffe Break |
|
3:00 pm - 3:30 pm
|
Robert H. Edwards (University of California - San Francisco, USA)
"Vesicular glutamate transporter 1 uses multiple pathways for endocytosis at the nerve terminal" |
|
3:30 pm - 4:00 pm
|
Kathy Geering (University of Lausanne, Switzerland)
"Protein-Protein Interaction and Transporter Regulation: FXYD proteins and (Na+K)-ATPase" |
|
5:15 pm - 9:15 pm
|
Zentrum Paul Klee Tour and Dinner – Tour of Paul Klee Museum with Apéro and dinner |
|
| |
| THURSDAY |
| 9:00 am - 11:30 pm |
Critical analyses of different in vitro methods for transporter based pharmacology investigations |
|
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Chair: Hans Lennernäs (Uppsala University, Sweden) |
| |
|
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9:00 am - 9:30 am |
Dietrich Keppler (DKFZ, Heidelberg, Germany)
"Integrated action of uptake and elimination transport: from in vivo studies to cellular models"
|
|
9:30 am - 10:00 am |
Hans Lennernäs (Uppsala University, Sweden)
"Liver clearance: an in vivo perspective of liver uptake and biliary excretion"
|
|
10:00 am - 10:30 am |
Coffee Break |
|
10:30 am - 11:00 am |
Olavi Pelkonen (Oulu University, Finland)
"A critical analysis of the use of in vitro models in modern drug discovery and development" |
|
11:00 am - 11:30 pm |
Keith Hoffmaster (Pfizer, Cambridge, MA, USA)
"Current and future approaches for hepatic transporter investigation research in the pharmaceutical industry" |
|
11:30 pm - 12:30 pm |
Lunch |
|
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| 12:30 pm - 3:00 pm |
Drug discovery technologies |
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Chair: Bob Burrier (Invitrogen, Grand Island, NY, USA) |
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|
|
12:30 pm - 1:00 pm |
Anthony S. Basile (DOV Pharmaceutical, Inc, Somerset, NJ, USA)
"The cyclic evolution of monoamine neurotransmitter uptake inhibitors: from TCAs to TRIPs"
|
|
1:00 pm - 1:30 pm |
Bela Kelety (IonGate Biosciences, Frankfurt, Germany)
"Cell free electrophysiology, a platform for transporter drug discovery"
|
|
1:30 pm - 2:00 pm |
Jun Otomo (Hitachi Co., Ltd, Tokyo, Japan)
"Hightroughput oocyte expression of transporter genes for drug discovery"
|
|
2:00 pm - 2:30 pm |
Coffee Break
|
|
2:30 pm - 3:00 pm |
Kenneth R. Brouwer (Qualyst, Inc., Raleigh, NC, USA)
""Application of B-CLEAR(Sandwich-Cultured Hepatocytes) in the evaluation of drug transport in drug discovery and development"
|
| |
|
|
3:00 pm - 5:00 pm |
Effect of genetic polymorphism (GPs) and drug-drug interaction on clinically relevant transporter-mediated PK and PD alterations
|
| |
Chair: Yuichi Sugiyama (University of Tokyo, Japan) |
| |
|
|
3:00 pm - 3:30 pm |
Yuichi Sugiyama (University of Tokyo, Japan)
"Integration of in vitro and in vivo data of DDI and GPs based on PBPK modeling"
|
|
3:30 pm - 4:00 pm |
Leslie Benet (University of California - San Francisco, CA, USA)
"Interplay of enzymes and transporters in DDI and in predicting the relevance of genetic
polymorphisms"
|
|
4:00 pm - 4:30 pm |
Christiane Pauli-Magnus (University Hospital of Basel, Switzerland)
"GPs and DDI of hepatic transporters"
|
|
4:30 pm - 5:00 pm |
Reinhold Kerb (AstraZeneca, Mölndal, Sweden)
"Contribution of genetic variation in transport proteins to drug response"
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| FRIDAY |
| Departure |
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