Matthias A Hediger
Harvard Medical School
Boston, MA, USA
  Peter Meier- Abt
University of Zurich
Zurich, Switzerland

Robert Burrier
Grand Island, NY, USA

Ken-ichi Inui
Kyoto University
Kyoto, Japan


BioMedical Transporters 2005 - Bridging Basic and Applied Sciences:

August 14-18, 2005
Olma Congress Center, St. Gallen , Switzerland

Organizer: Matthias Hediger (University of Bern, Switzerland)

Co-Organizers: Peter Meier- Abt (University of Basel, Switzerland), Robert Burrier (Invitrogen, Grand Island, NY), and Ken-ichi Inui (Kyoto University, Japan)

4:00 pm - 8:00 pm Registration

6:00 pm – 10:00 pm

9:00 am - 12:10 pm SLC Transporters - Human Transporter families, their roles in human diseases and their potential in drug discovery, part I
  Chair: Hitoshi Endou (Fuji Biomedix Co., Ltd)
8:15 am - 8:30 am Matthias A. Hediger - Welcome
8:30 am - 9:00 am Christopher P. Landowski (University of Bern, Switzerland)
"An overview of the SLC series of transporters"
9:00 am - 9:40 am Peter J. Meier-Abt (University of Basel, Switzerland)
"Organic anion and cation transporters"
9:40 am - 10:20 am Yoshikatsu Kanai (Kyorin University School of Medicine, Tokyo, Japan)
"Amino acid transporters in cancer biology"
10:20 am - 10:50 am Coffee Break
10:50 am - 11:30 am Joachim Geyer (University of Giessen, Germany)
"SLC10: More than a family of bile acid transporters"
11:30 am - 11:50 am Marieangela C. Wilson (University of Bristol, UK)
"GP70 is the ancillary protein for monocarboxylate transporter MCT2 and accounts for its insensitivity to organomercurials"
11:50 am - 12:10 pm Farrukh A. Chaudhry (University of Oslo, Norway)
"Regulation of glutamine transport at physiological conditions and in pathology"
12:10 pm – 1:10 pm Lunch
1:10 pm - 5:00 pm Non-SLC Transporters (ABC Transporters and Pumps) –Human Transporter families, their roles in human diseases and their potential in drug discovery, part II:
  Chair: Bruno Stieger (University of Zürich, Switzerland)
1:10 pm - 1:50 pm

Kaspar P. Locher (ETH Zürich , Switzerland)
“ABC transporter architecture and mechanism”

1:50 pm - 2:30 pm

Peter Dimroth (ETH Zürich , Switzerland)
“Proteins in motion: Coupling electrochemical gradients to ATP synthesis”

2:30 pm - 3:10 pm

Alfred H. Schinkel (The Netherlands Cancer Institute, Amsterdam)
“ABC mulitdrug transporters: biological and pharmacological roles”

3:10 pm - 3:40 pm Coffee Break
3:40 pm - 4:20 pm Yiannis A. Ioannou (Mount Sinai School of Medicine, New York, NY)
"RND (resistance nodulation division) lipid transporters: Subcellular gate keepers"
4:20 pm - 4:40 pm Johannes Noé (F.Hoffmann-La Roche Ltd, Switzerland)
"MRP2 and BSEP mediated troglitazone sulfate transport and its possible implications for troglitazone associated hepatotoxicity"
4:40 pm - 5:00 pm Christiane Albrecht (Technische Universität München, Germany)
"Defective expression and aberrant function of ABCA1 in a patient with Scott syndrome - novel links between apoptosis, haemostasis and atherosclerosis"
Evening Enjoy St. Gallen (no planned events)
9:00 am - 12:10 pm Drug Targets part I:
  Chair: Peter Meier-Abt (University Basel, Switzerland)
9:00 am - 9:40 am

Scott W. Altmann (Schering-Plough Research Institute, Kenilworth, NJ)
“Cholesterol absorption via NPC1L1”

9:40 am - 10:20 am Klaus Dembowsky (Ingenium Pharmaceuticals, Martinsried, Germany)
"Missense mutation of a transporter of the major facilitator superfamily changes plasma membrane composition and elevates insulin sensitivity"
10:20 am - 10:50am Coffee Break
10:50 am - 11:30 am Matthias A. Hediger (University of Bern, Switzerland)
"The roles of calcium channel trpv6 in calcium homeostasis: New lessons from knockout mice and therapeutic perspectives"
11:30 am - 11:50 am Graham P. Belfield (AstraZeneca R&D Charnwood, UK)
"Functional characterisation of cloned MCT family members & the pharmacological analysis of selective inhibitors of MCT1"
11:50 am - 12:10 pm Naohiko Anzai (Kyorin University School of Medicine, Japan)
"Regulation of renal urate/anion exchanger URAT1 transport function by PDZ domain protein PDZK1: Effect of PDZK1 SNPs"
12:10 pm - 1:10 pm Lunch
Afternoon No planned events – enjoy beautiful “Old City” St. Gallen
5:00 pm - 7:00 pm Wine and Cheese Poster Session
7:00 pm - 9:20 pm Drug Discovery Technologies
  Chair: Robert Burrier (Invitrogen Grand Island, NY, USA)
7:00 pm - 7:40 pm

Hans Lennernäs (Uppsala University, Sweden)
"Human intestinal perfusion: an approach to investigate intestinal and biliary excretion of drugs and metabolites in vivo"

7:40 pm - 8:20 pm

Stephen D. Hess (Invitrogen, WI, USA)
"Use of Voltage-Sensing FRET probes to build ion channel and transporter assays"

8:20 pm - 9:00 pm

Andreas Rolfs (Harvard Medical School, MA, USA)
"High Throughput Functional Proteomics - Synthesis and usage of ORF collections in vitro and in vivo"

9:00 pm - 9:20 pm Martin Knöpfel (Tracechem, Switzerland)
"A simple membrane model for novel findings on trace element transport"
8:30 am - 12:20 pm Structure of membrane transporters and structure-based rational drug design


Chair: Werner Kühlbrandt
(Max-Planck-Institute of Biophysics, Frankfurt, Germany)
8:30 am - 9:10 am

Werner Kühlbrandt
(Max-Planck-Institute of Biophysics, Frankfurt , Germany)
"Structure and mechanisms of Na+/H+ antiporters"

9:10 am - 9:50 am

Sriram Subramaniam (National Cancer Institute, NIH, MD, USA)
"Structural analysis of membrane transporters and receptors by 3D electron microscopy"

9:50 am - 10:20 am

Coffee Break

10:20 am - 11:00 am

Eva Pebay-Peyroula (Université Joseph Fourier, France)
“Mitochondrial ADP/ATP Carrier”

11:00 am - 11:40 am

Chris G. Tate (Medical Research Council Laboratory of Molecular Biology,
Cambridge, UK )
"Structure and oligomeric state of the bacterial multidrug transporter EmrE"

11:40 am - 12:00 pm Karen McLuskey (University of Leeds, UK)
"The Membrane Protein Structure Initiative (MPSI): A Glasgow perspective"
12:00 pm - 12:20 pm Rosalinde Masereeuw (University Nijmegen Medical Centre, The Netherlands)
"Apical expression of the organic anion transporting polypeptides, Oatp1a5 and Oatp1a6, in rat kidney proximal tubule"
12:20 pm - 1:20 pm Lunch
1:20 pm - 5:10 pm Drug Targets part II


Chair: Carlo Brugnara (Harvard Medical School, MA, USA)
1:20 pm - 2:00pm Jean-Yves Lapointe (University of Montreal, Canada)
"SMCT is a Na+-monocarboxylate cotransporter encoded by SLC5A8, a tumour suppressor gene in colon cancer"
2:00pm - 2:40pm Noa Zerangue (XenoPort, CA, USA)
"Transporter-directed targeting of chemotherapeutic agents to achieve selective accumulation in solid tumors."
2:40 pm - 3:20 pm Carlo Brugnara (Harvard Medical School, MA, USA)
"From clotrimazole to novel drugs for sickle cell disease, cancer and diarrhea"
3:20 pm - 3:50 pm Coffee Break
3:50 pm - 4:30 pm Gordon Amidon (University of Michigan, USA)
"Drug targeting using membrane transporters and activating enzymes:
Application to anticancer and antiviral nucleoside drugs"
4:30 pm - 5:10 pm I. David Goldman (Albert Einstein College of Medicine, NY, USA)
"Membrane transport processes that determine the activity of antifolate cancer chemotherapeutics"
5:45 pm – 10:30

Special Excursion to Mount Säntis
Enjoy the scenic views of the Alps (includes Dinner)

9:00 am - 12:30 pm Drug Transporter-Drug Metabolism Interplay


Chair: Leslie Z. Benet (University of California, San Francisco, CA)
9:00 am - 9:40 am

Leslie Z. Benet (University of California, San Francisco, USA)
"Overview of transporter-enzyme interplay"

9:40 am - 10:20 am

Jiunn H. Lin (Merck Research Laboratories, PA, USA)
"Inhibition aspects of transporter-enzyme interplay as they affect drug development"

10:20 am - 10:50 am

Coffee Break

10:50 am - 11:30 am Rommel G. Tirona (Vanderbilt University, TN, USA)
"Induction and activation aspects of transporter-enzyme interplay as they affect drug development"
11:30 am - 12:10 pm Jashvant D. Unadkat ( University of Washington, Seattle, WA)
"P-glycoprotein activity at the blood brain barrier: extrapolating from rodents to humans"
12:10 pm - 12:30 pm Katherine Fenner (Pfizer Global Research and Development, UK)
"The evaluation and comparison of an immortalised rat brain endothelial cell line with cells expressing specific transport proteins"
12:30 pm - 1:30 pm Lunch
1:30 pm - 4:50 pm Drug Transport
  Chair: Ken-ichi Inui (Kyoto University, Japan)
1:30 pm - 2:10 pm

Ken-ichi Inui (Kyoto University Hospital, Japan)
"Clinical implications of drug transporters”

2:10 pm - 2:50 pm

Akira Tsuji ( Kanazawa University, Japan)
"Protein-protein interaction involved in regulation of function and expression of organic cation/carnitine transporter OCT/OCTN family"

2:50 pm - 3:30 pm

Kathleen M. Giacomini (University of California, San Francisco)
"Pharmacogenomics of drug transporters”

3:30 pm - 4:00 pm Coffee Break
4:00 pm - 4:40 pm

Yuichi Sugiyama (University of Tokyo, Japan)
"Prediction of transporter-based drug interactions"

4:40 pm - 5:20 pm

David E. Smith ( University of Michigan , USA)
“Role and relevance of PEPT2 in the brain and kidney: In vivo implications for drug delivery and disposition”

7:00 pm Farewell Dinner: Hotel Ekkehard