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BioMedical Transporters 2005 - Bridging Basic and Applied Sciences:
August 14-18, 2005
Switzerland
Olma Congress Center, St. Gallen , Switzerland
Organizer: Matthias
Hediger (University of Bern, Switzerland)
Co-Organizers:
Peter Meier- Abt (University
of Basel, Switzerland),
Robert Burrier (Invitrogen, Grand
Island, NY), and Ken-ichi Inui (Kyoto
University, Japan)
| SUNDAY |
| 4:00 pm - 8:00 pm |
Registration |
|
|
Reception |
|
| |
| MONDAY |
| 9:00
am - 12:10 pm |
SLC
Transporters - Human Transporter families,
their roles in human diseases and their potential
in drug discovery, part I |
| |
Chair:
Hitoshi Endou (Fuji Biomedix Co., Ltd) |
| |
|
| 8:15
am - 8:30 am |
Matthias A.
Hediger - Welcome |
| 8:30
am - 9:00 am |
Christopher
P. Landowski (University of Bern,
Switzerland)
"An overview of the SLC series of transporters" |
|
9:00 am - 9:40 am |
Peter
J. Meier-Abt (University of Basel,
Switzerland)
"Organic anion and cation transporters"
|
|
9:40 am - 10:20 am |
Yoshikatsu
Kanai (Kyorin University School
of Medicine, Tokyo, Japan)
"Amino acid transporters in cancer biology"
|
|
10:20 am - 10:50 am |
Coffee Break
|
|
10:50 am - 11:30 am |
Joachim Geyer (University of Giessen,
Germany)
"SLC10: More than a family of bile acid
transporters" |
|
11:30 am - 11:50 am |
Marieangela
C. Wilson (University of Bristol, UK)
"GP70 is the ancillary protein for monocarboxylate
transporter MCT2 and accounts for its insensitivity
to organomercurials" |
|
11:50 am - 12:10 pm |
Farrukh A. Chaudhry (University of
Oslo, Norway)
"Regulation of glutamine transport at
physiological conditions and in pathology" |
|
12:10 pm – 1:10 pm |
Lunch |
|
| |
| 1:10
pm - 5:00 pm |
Non-SLC
Transporters (ABC Transporters and Pumps)
–Human Transporter families, their roles in
human diseases and their potential in drug
discovery, part II: |
| |
Chair:
Bruno Stieger (University
of Zürich, Switzerland) |
| |
|
|
1:10 pm - 1:50 pm |
Kaspar P. Locher (ETH
Zürich , Switzerland)
“ABC transporter architecture and mechanism”
|
|
1:50 pm - 2:30 pm |
Peter Dimroth (ETH Zürich
, Switzerland)
“Proteins in motion: Coupling electrochemical
gradients to ATP synthesis”
|
|
2:30 pm - 3:10 pm |
Alfred H. Schinkel (The
Netherlands Cancer Institute, Amsterdam)
“ABC mulitdrug transporters: biological
and pharmacological roles”
|
| 3:10
pm - 3:40 pm |
Coffee Break |
|
3:40 pm - 4:20 pm |
Yiannis
A. Ioannou (Mount Sinai School of
Medicine, New York, NY)
"RND (resistance nodulation division) lipid
transporters: Subcellular gate keepers" |
|
4:20 pm - 4:40 pm |
Johannes
Noé (F.Hoffmann-La Roche Ltd, Switzerland)
"MRP2 and BSEP mediated troglitazone
sulfate transport and its possible implications
for troglitazone associated hepatotoxicity" |
| 4:40
pm - 5:00 pm |
Christiane
Albrecht (Technische Universität
München, Germany)
"Defective expression and aberrant function
of ABCA1 in a patient with Scott syndrome
- novel links between apoptosis, haemostasis
and atherosclerosis" |
|
Evening |
Enjoy St. Gallen
(no planned events) |
|
| |
| TUESDAY |
| 9:00
am - 12:10 pm |
Drug
Targets part I: |
| |
Chair:
Peter Meier-Abt (University
Basel, Switzerland) |
| |
|
|
9:00 am - 9:40 am |
Scott W. Altmann (Schering-Plough
Research Institute, Kenilworth, NJ)
“Cholesterol absorption via NPC1L1” |
|
9:40 am - 10:20 am |
Klaus
Dembowsky (Ingenium Pharmaceuticals,
Martinsried, Germany)
"Missense mutation of a transporter of
the major facilitator superfamily changes
plasma membrane composition and elevates insulin
sensitivity" |
|
10:20 am - 10:50am |
Coffee Break |
|
10:50 am - 11:30 am |
Matthias
A. Hediger (University of Bern, Switzerland)
"The roles of calcium channel trpv6 in calcium homeostasis: New lessons from knockout mice and therapeutic perspectives" |
|
11:30 am - 11:50 am |
Graham P. Belfield (AstraZeneca R&D
Charnwood, UK)
"Functional characterisation of cloned
MCT family members & the pharmacological
analysis of selective inhibitors of MCT1" |
|
11:50 am - 12:10 pm |
Naohiko Anzai (Kyorin University School
of Medicine, Japan)
"Regulation of renal urate/anion exchanger
URAT1 transport function by PDZ domain protein
PDZK1: Effect of PDZK1 SNPs" |
|
12:10 pm - 1:10 pm |
Lunch |
|
Afternoon |
No planned
events – enjoy beautiful “Old City” St. Gallen
|
|
5:00 pm - 7:00 pm |
Wine
and Cheese Poster Session |
|
| |
| 7:00
pm - 9:20 pm |
Drug
Discovery Technologies |
| |
Chair:
Robert Burrier (Invitrogen Grand Island, NY,
USA) |
| |
|
| 7:00
pm - 7:40 pm |
Hans Lennernäs (Uppsala
University, Sweden)
"Human intestinal perfusion: an approach
to investigate intestinal and biliary excretion
of drugs and metabolites in vivo"
|
|
7:40 pm - 8:20 pm |
Stephen D. Hess (Invitrogen, WI, USA)
"Use of Voltage-Sensing FRET probes to build
ion channel and transporter assays"
|
|
8:20 pm - 9:00 pm |
Andreas Rolfs (Harvard
Medical School, MA, USA)
"High Throughput Functional Proteomics
- Synthesis and usage of ORF collections
in vitro and in vivo"
|
|
9:00 pm - 9:20 pm |
Martin Knöpfel (Tracechem, Switzerland)
"A simple membrane model for novel findings
on trace element transport" |
|
| |
| WEDNESDAY |
| 8:30
am - 12:20 pm |
Structure
of membrane transporters and structure-based
rational drug design |
|
|
Chair:
Werner Kühlbrandt
(Max-Planck-Institute of Biophysics, Frankfurt,
Germany) |
| |
|
|
8:30 am - 9:10 am |
Werner Kühlbrandt
(Max-Planck-Institute of Biophysics, Frankfurt
, Germany)
"Structure and mechanisms of Na+/H+
antiporters"
|
|
9:10 am - 9:50 am |
Sriram Subramaniam (National
Cancer Institute, NIH, MD, USA)
"Structural analysis of membrane transporters
and receptors by 3D electron microscopy"
|
|
9:50 am - 10:20 am |
Coffee Break
|
|
10:20 am - 11:00 am |
Eva Pebay-Peyroula (Université
Joseph Fourier, France)
“Mitochondrial ADP/ATP Carrier”
|
|
11:00 am - 11:40 am |
Chris G. Tate (Medical
Research Council Laboratory of Molecular
Biology,
Cambridge, UK )
"Structure and oligomeric state of
the bacterial multidrug transporter EmrE"
|
| 11:40
am - 12:00 pm |
Karen
McLuskey (University of Leeds, UK)
"The Membrane Protein Structure Initiative
(MPSI): A Glasgow perspective" |
|
12:00 pm - 12:20 pm |
Rosalinde Masereeuw (University Nijmegen
Medical Centre, The Netherlands)
"Apical expression of the organic anion
transporting polypeptides, Oatp1a5 and Oatp1a6,
in rat kidney proximal tubule" |
|
12:20 pm - 1:20 pm |
Lunch |
|
| |
| 1:20
pm - 5:10 pm |
Drug
Targets part II |
|
|
Chair: Carlo
Brugnara (Harvard Medical School, MA, USA) |
| |
|
|
1:20 pm - 2:00pm |
Jean-Yves
Lapointe (University of Montreal,
Canada)
"SMCT is a Na+-monocarboxylate cotransporter
encoded by SLC5A8, a tumour suppressor gene
in colon cancer" |
|
2:00pm - 2:40pm |
Noa
Zerangue (XenoPort, CA, USA)
"Transporter-directed targeting of chemotherapeutic
agents to achieve selective accumulation in
solid tumors." |
| 2:40
pm - 3:20 pm |
Carlo
Brugnara (Harvard Medical School,
MA, USA)
"From clotrimazole to novel drugs for sickle
cell disease, cancer and diarrhea" |
| 3:20
pm - 3:50 pm |
Coffee Break |
| 3:50
pm - 4:30 pm |
Gordon
Amidon (University of Michigan,
USA)
"Drug targeting using membrane transporters
and activating enzymes:
Application to anticancer and antiviral nucleoside
drugs" |
| 4:30
pm - 5:10 pm |
I. David
Goldman (Albert Einstein College
of Medicine, NY, USA)
"Membrane transport processes that determine
the activity of antifolate cancer chemotherapeutics" |
|
5:45 pm – 10:30 |
Special Excursion to Mount Säntis
Enjoy the scenic views of the Alps (includes
Dinner)
|
|
| |
| THURSDAY |
| 9:00
am - 12:30 pm |
Drug
Transporter-Drug Metabolism Interplay |
|
|
Chair: Leslie
Z. Benet (University of California,
San Francisco, CA) |
| |
|
|
9:00 am - 9:40 am |
Leslie Z. Benet (University
of California, San Francisco, USA)
"Overview of transporter-enzyme interplay"
|
|
9:40 am - 10:20 am |
Jiunn H. Lin (Merck Research Laboratories,
PA, USA)
"Inhibition aspects of transporter-enzyme
interplay as they affect drug development"
|
|
10:20 am - 10:50 am |
Coffee Break |
|
10:50 am - 11:30 am |
Rommel
G. Tirona (Vanderbilt University,
TN, USA)
"Induction and activation aspects of transporter-enzyme
interplay as they affect drug development"
|
|
11:30 am - 12:10 pm |
Jashvant
D. Unadkat ( University of Washington,
Seattle, WA)
"P-glycoprotein activity at the blood
brain barrier: extrapolating from rodents
to humans" |
|
12:10 pm - 12:30 pm |
Katherine Fenner (Pfizer Global Research
and Development, UK)
"The evaluation and comparison of an
immortalised rat brain endothelial cell line
with cells expressing specific transport proteins" |
|
12:30 pm - 1:30 pm |
Lunch |
|
| |
| 1:30
pm - 4:50 pm |
Drug
Transport |
| |
Chair: Ken-ichi
Inui (Kyoto University, Japan) |
| |
|
|
1:30 pm - 2:10 pm |
Ken-ichi Inui (Kyoto
University Hospital, Japan)
"Clinical implications of drug transporters”
|
|
2:10 pm - 2:50 pm |
Akira Tsuji ( Kanazawa
University, Japan)
"Protein-protein interaction involved
in regulation of function and expression
of organic cation/carnitine transporter
OCT/OCTN family"
|
|
2:50 pm - 3:30 pm |
Kathleen M. Giacomini
(University of California, San Francisco)
"Pharmacogenomics of drug transporters”
|
| 3:30
pm - 4:00 pm |
Coffee Break |
|
4:00 pm - 4:40 pm |
Yuichi Sugiyama (University
of Tokyo, Japan)
"Prediction of transporter-based drug
interactions"
|
|
4:40 pm - 5:20 pm |
David E. Smith ( University
of Michigan , USA)
“Role and relevance of PEPT2 in the brain
and kidney: In vivo implications for drug
delivery and disposition”
|
|
7:00 pm |
Farewell
Dinner: Hotel Ekkehard |
|
| |
| FRIDAY |
| Departure |
| |
|
|
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