Program – Biomedical Transporters 2001
Interlaken, Switzerland
Sunday, August 5
4-8 PM Registration
6-10 PM Reception
Monday, August 6
AM
Welcome
Matthias A. Hediger (Harvard Medical School, Boston, MA), Robert Burrier (GelTex Pharmaceuticals, Inc., Waltham, MA), Wolf Frommer (University of Tübingen), Peter Meier-Abt (University of Zürich, Switzerland), Heini Murer (University of Zürich, Switzerland)
Overview - Transporter Superfamilies: Matthias A. Hediger
Session I – Mono- and disaccharide transporters: Chairs Wolf Frommer and Ernest Wright
Ernest Wright (University of California, Los Angeles) - The SGLT Family (SLC5): Structure and Diverse Function of Sodium Cotransporters
Mike Mueckler ( Washington University School of Medicine, St. Louis, MO) – The SLC2 family of glucose transporters (GLUT1 to GLUT8)
Eckhard Boles ( University of Düsseldorf, Germany) - Glucose transporters as targets for drug screening: using yeast mutants as a heterologous screening system
Widmar Tanner (University of Regensburg, Germany) - Glucose transport in plants
PM
Session I – Continued
Wolf Frommer (University of Tübingen) - The disaccharide transporter superfamily: Sucrose transporters in plants
Session II – The oligopeptide transporter superfamily (SLC 15): Chair Ron Barrett
Hannelore Daniel (Technical University of Munich) - The peptide transporter superfamily: Physiological and pharmacological implications
Ron Barrett (Xenoport, Inc., Palo Alto, CA) – Improving Drug Bioavailability by Engineering Active Transport
Session III – Amino acid transporter superfamilies: Chair Manuel Palacin
Manuel Palacin (University of Barcelona, Spain) – The Amino Acid Permease Superfamily (SLC7) and cystinuria
Sela Mager (University of North Carolina, Chapel Hill, NC) – The GABA/neurotransmitter/amino acid transporter superfamily (SLC6)
Michael Kavanaugh (Oregon Health Sciences University, Portland, OR) - Glutamate transporters: Structure, pharmacology and roles in physiology and pathophysiology (SLC1 superfamily)
Jeffrey Erickson (Louisiana State University, New Orleans, LA) – The SLC38 (Systems A and N) and SLC17 (vesicular glutamate transporters) superfamilies
Evening - Enjoy Interlaken! (No planned events)
Tuesday, August 7
AM
Session IV – The nucleoside, bile acid, organic anion, organic and cation transporter superfamilies (SLC10, 21, 22, 28 and 29) - Chair: Kathleen Giacomini
Kathleen Giacomini (University of California San Francisco) – Organic cation and nucleoside transporters, and their relevance to drug absorption and elimination
Peter Meier (University of Zürich, Switzerland) - Bile acid and organic anion transporters
Hitochi Endou (Kyorin University, Tokyo) - Role of SLC22 family members in human pharmacokinetics
PM
Jungfraujoch Excursion
Evening
Session V – Novel insights into the structure and function of transporters and channels: Implications for drug discovery (Chair Alan Verkman, University of San Francisco)
Joe Mindell (Brandeis University, Waltham, MA) – Crystal structure of a ClC channel
Alan Verkman (University of California San Francisco) - CFTR and aquaporins as targets for drug discovery
Yoshikatsu Kanai (Kyorin University School of Medicine, Tokyo) – System T amino acid transporter: Molecular identification and pharmacological properties
Vladivel Ganapathy (Medical College of Georgia Augusta, GA 30912, USA) – Pharmacology and therapeutic use of the amino acid transporter ATB0,+
Wednesday, August 8
AM
Session VI – Drug discovery strategies and technologies (Chair Robert Burrier, GelTex Pharmaceuticals, Inc., Waltham, MA)
Robert Burrier(GelTex, MA) - Introduction on the Integration of Drug Discovery, High-throughput Screening, and Transporter Biology
Werner Kramer (Aventis Pharma, Frankfurt, Germany) - Discovery of Inhibitors of the Sodium Dependent Bile Acid Transporter
Thomas Large ( Eli Lilly & Co., Indianapolis, IN) - Choosing a high throughput screening format for ion channels and transporters.
Michael Xie ( Millennium Pharmaceuticals, Cambridge, MA) - Assay development for electrogenic transporters using a novel fluorescent membrane potential dyes
Tito Gonzalez (Aurora Biosciences, San Diego, CA) - High-throughput technologies for ion transport functional analysis and drug discovery
Lisa Higgins (Elan Corporation, Dublin) - The use of TOGA(TM) to
identify membrane receptors and transporters in in
vitro and in vivo models of human Peyer's patch M cells
PM
Session VII – Physiological Implications and commercial opportunities in the transporter field (Chair George Sachs, University of California Los Angeles)
George Sachs – UreI-mediated urea transport in Helicobacter pylori
Heini Murer (University of Zürich, Switzerland) - Epithelial phosphate transporters
Anne-Marie Marini ( Universite Libre de Bruxelles, Belgium) - From yeast ammonium transporters to human Rhesus polypeptides
Donald Hilgemann (University of Texas Southwestern) - Lipid signaling and ion transport
Soraya Shirazi-Beechey (University of Liverpool, UK) – Molecular characterisation and regulation of a monocarboxylate transporter (MCT, SLC16) in human colon
Stefan Silbernagl (Universität Würzburg, Germany) – Renal Tubular Transport of myo-inositol in vivo
Evening
Special Dinner/ Entertainment (Swiss Evening)
Thursday, August 9
AM
Session VIII - Fatty acid and cholesterol transporters (SLC27, ABC transporters, etc.) (Chair Louis Tartaglia, Millennium Pharmaceuticals, Cambridge, MA)
Richard M. Lawn (CV Therapeutics, Palo Alto, CA) - ABC transporters and cholesterol metabolism
Monty Krieger (Massachusetts Institute of Technology, Cambridge, MA) - Charting the Fate of the "Good Cholesterol" - Physiologic and Genetic Analysis of the HDL Receptor SR-BI
Nada Abumrad (Stony Brook, NY) - The role of CD36 in facilitating fatty acid transport
Ruth Gimeno (Massachusetts Institute of Technology, Cambridge, MA) - Fatty Acid Transport Proteins (FATPs)
PM
Session IX – Membrane transporters in the choroid plexus (Chair Jean-François Ghersi-Egea, INSERM, Lyon, France)
Jean-François Ghersi-Egea - The blood-brain interfaces in cerebral pharmaco-toxicology. Contribution of an in vitro cellular model to study choroidal transport
Michel Lemaire (Novartis Pharma AG, Basel, Switzerland) - Importance of blood-brain interface transporters in drug development
Kathleen Giacomini (University of California San Francisco) – Nucleoside transporters at the CP (tentative)
John B. Pritchard (NIH, Research Triangle Park, NC) - Organic anion transporters (OAT) and organic cation transporters (OCT) families at the choroid plexus
Yuichi Sugiyama (University of Tokyo) - Drug transport and efflux at the choroid plexus: from in vivo studies to molecular identification of transporters
Choroid plexus/hepatobiliary Keynote Lecture
Peter Meier (University of Zürich, Switzerland) - "Epithelial Transport Polarity:
Similarities and differences between the choroid plexus and the liver"
Evening
Choroid Plexus/Hepatobiliary Dinner
Session X - Hepatobiliary transport session (Chair - Bruno Stieger, University of Zürich, Switzerland) (7:30 pm to 9:30 pm)
Deitrich Keppler and Jörg König (Deutsches Krebsforschungszentrum, Heldelberg, Germany) - ABC-transporters in the liver
Michael Muller (Wageningen, The Netherlands) - Transcriptional regulation of hepatocellular transporters
R. Oude Elferink (Amsterdam, The Netherlands) - Hepatic cholesterol and lipid transport
Friday (August 10)
Hepatobiliary Transport Satellite Meeting
Organizers: Bruno Stieger (University of Zürich), Peter Meier-Abt (University of Zürich), Matthias A. Hediger (Harvard Medical School) and Oude Elferink (University of Amsterdam)
7:30 - 8:00 AM Registration
8:15 AM
Opening Remarks: Peter Meier and Bruno Stieger (University of
Zürich, Switzerland)
Session H1: Gerd A. Kullak-Ublick (University Hospital Zürich, Switzerland) - Chair
8:30 AM:
Jenny Ros and Klaas Nic Faber (University Hospital Groningen, The Netherlands)
- ABC Transporter Gene Expression in Hepatic Progenitor Cells
9:00 AM
Diana Jung and Gerd A. Kullak-Ublick (University Hospital Zürich, Switzerland)
- Regulation of Liver-Specific OATP-Genes by Hepatocyte Nuclear Factor 1
9:30 AM
Michael Trauner and Gernot Zollner (Karl Franzens University, Graz, Austria)
-
Role of the Transcriptional Regulation Repressor SHP-1 for Down-Regulation of
Ntcp in Bile Duct Ligated Mice
10:00 - 10:30 AM: Coffee Break
Session H2: Dirk Meijer (Groningen University Institute for
Drug Exploration, The Netherlands) - Chair
10:30 AM
Marieke Eleferink and Dirk Meijer (Groningen University Institute
for Drug Exploration, The Netherlands) - Regulation and Perturbation
of Hepatobiliary Membrane Transport in Liver Disease
11:00 AM
Ulrich Beuers and Christian Rust (Klinikum Grosshadern, University of Munich,
Germany) -Taurolithocholic Acid Impairs Hepatobiliary Exocytosis, Bile
Acid and Organic Anion Secretion by a Phosphadiylinositol 3-Kinase-Dependent
Mechanism
11:30 AM
Christoph Dietrich and Ronald Oude Elferink (Academic Medical Center, University
of Amsterdam, The Netherlands) - Mrp2-Mediated Liver Injury, the Flip-Side
of Concentrative Transport
12:00 Noon
Carlo Spirli (Department of Medical and Surgical Sciences, University of
Padova, Italy) - Glibenclamide-Stimulated Secretion in Bile Duct Epithelium
and Role of p-gp
1230-1330: Lunch
Session H3: Ronald Oude Elferink (Academic Medical Center,
University of Amsterdam, The Netherlands) - Chair
1:30 PM
Edith Friesema and Theo Visser (Erasmus University Medical School, Rotterdam,
The Netherlands) - Characterization of Hepatic Thyroid Hormone Transporters
2:00 PM
Jane Bryne, Sandra Strautnieks and Richard Thompson (King's College Hospital
London, UK) - University Hospital Groningen, Groningen, The Netherlands)
- The Problems of Expressing Human BSEP in vitro
2:30 PM
Anne Figge and Frank Lammert (Universitätsklinikum, Rheinisch-Westfalische
Technische Hochschule, Aachen, Germany) - Genomic Analysis of Hepatobiliary
Lipid Transport in Inbred Mouse Models
3:00 PM
Saskia van Mil and Leo Klomp (University Medical Center Utrecht, Utrecht,
The Netherlands) - Mechanisms of Copper Homeostasis: Lessions from Yeast
and Man
3:30 PM
Peter and Meier and Bruno Stieger -
General Discussion: Future of the European Heptobiliary Transport Group
4:30 PM Concluding Remarks - Hepatobiliary Transport Meeting
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