SLC41: The MgtE-like magnesium transporter family
Proposed
New Human
Gene Name
Current human
gene
name
Protein
Name
Predominent
Substrates
Transport type
Coupling ions
Tissue distribution &
cellular/subcellular
expression
Link to
disease
Human gene
locus
Sequence
Accession ID
Splice variants
and their features
SLC41A1
Mg2+, Sr2+, Zn2+, Cu2+, Fe2+, Co2+, Ba2+, Cd2+
heart, testis, skeletal muscle, prostate, adrenal gland, thyroid - low expression in most tissues
1q32.1
NM_173854
SLC41A2
Mg2+, Ba2+, Ni2+, Co2+, Fe2+, Mn2+
12q23.3
NM_032148
SLC41A3
3q21.2
NM_017836
References: Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, Bruford EA. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins: Introduction. Pflugers Arch. 2004 Feb;447(5):465-8.