SLC41: The MgtE-like magnesium transporter family

Proposed

New Human

Gene Name

Current human

gene

name

Protein

Name

Predominent

Substrates

Transport type

Coupling ions

Tissue distribution &

cellular/subcellular

expression

Link to

disease

Human gene

locus

Sequence

Accession ID

Splice variants

and their features

 

SLC41A1

 

 

 

Mg2+, Sr2+, Zn2+, Cu2+, Fe2+, Co2+, Ba2+, Cd2+

 

heart, testis, skeletal muscle, prostate, adrenal gland, thyroid - low expression in most tissues

 

1q32.1

NM_173854

 

SLC41A2

 

 

 Mg2+, Ba2+, Ni2+, Co2+, Fe2+, Mn2+

 

 

 

 12q23.3

NM_032148

 

SLC41A3

 

 

 

 

 

 

 

3q21.2

NM_017836

 




References:

Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, Bruford EA. The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins: Introduction. Pflugers Arch. 2004 Feb;447(5):465-8.