SLC40: The basolateral iron transporter family

Human Gene

Name

Protein

Name

Aliases

Predominant Substrates

Transport type /Coupling ions *)

Tissue distribution and cellular/ subcellular expression

 

Link to disease #)

Human gene locus

Sequence

Accession

ID

Splice variants and their specific features

SLC40A1

IREG1

Ferroportin, MTP1

Ferrous iron

Facilitated?

Basolateral membrane in duodenum, spleen red pulp macrophages plasma membrane, liver kupffer cells PM,

Placenta, kidney

Type 4 haemochromatosis

  N144H

  A77D

 Val 162 deletion     G490D

 

2q32

NM_014585

Possible pseudogene ch 7 (near 7p15) NT_007819.10

*)
C: Cotransporter
E: Exchanger
F: Facilitated transporter
O: Orphan transporter

#)
A: Acquired defect
G: Genetic defect
P: Pseudogene




References:

Original version of the SLC table:

McKie AT, Barlow DJ. The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1). Pflugers Arch. 2004 Feb;447(5):801-6.