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SLC38:
The System A & N, sodium-coupled neutral amino acid transporter
family
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Human Gene
Name
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Protein
Name
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Former Aliases
|
Predominant
Substrates
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Transport
type / Coupling ionsa
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Tissue distribution
and cellular/ subcellular expression
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Human gene
locus
|
Sequence
Accession ID
|
Splice variants
and their specific features
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System A subfamily
|
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SLC38A1
|
SNAT1
|
ATA1
GlnT
NAT2
SA2
SAT1
|
Glutamine,
alanine, asparagine, cysteine, histidine, serine
|
C / Na+
|
Brain (glutamatergic
and GABAergic neurons, ependyma), retina, heart, placenta and
adrenal grand
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12q12-q13.11
|
NM_030674
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SLC38A2
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SNAT2
|
ATA2
KIAA1382
SA1
SAT2
|
Alanine,
asparagine, cysteine, glutamine, glycine, histidine, methionine,
proline, serine
|
C / Na+
|
Widespread,
including brain and spinal cord (neurons), placenta, adrenal glands,
testis, thymus, muscle, liver, intestine, kidney, lung, adipose,
spleen, skin
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12q
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NM_018976
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SLC38A3
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SNAT4
|
ATA3
FLJ10191
NAT3
PAAT
SAT3
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Alanine,
asparagine, cysteine, glycine, serine, threonine
|
C / Na+
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Liver, skeletal
muscle, kidney, pancreas
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12q13
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NM_006841
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2 splice
variants (identical ORFs) expressed in rat liver and skeletal
muscle
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System N subfamily
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SLC38A4
|
SNAT3
|
g17
NAT (mouse)
SN1
|
Glutamine,
histidine
|
C / Na+
+ E / H+
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Astrocytes
in the brain and retina; liver, kidney, and adipose
|
3p21.3
|
NM_018018
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|
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SLC38A5
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SNAT5
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JM24
SN2
|
Glutamine,
asparagine, histidine, serine (rat SNAT5 also accepts glycine,
alanine)
|
C / Na+
+ E / H+
|
Stomach,
brain, liver, lung, small intestine, spleen, colon, kidney
|
Xp11.23
|
NM_033518
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4 distinct
transcripts with differential tissue expression
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Orphan member
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SLC38A6
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SNAT6
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NAT-1 (human)
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Not tested
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Not tested
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Not tested
(ESTs in placenta, spleen, muscle, brain, lung)
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14q23.1
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NM_153811
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aC, cotransport; E, antiport. bThe former entry NM_018573 is obsolete
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