SLC37: The sugar-phosphate/phosphate exchanger family

Human Gene

Name

Protein

Name

Aliases

Predominant Substrates

Transport type /Coupling ions *)

Tissue distribution and cellular/ subcellular expression

 

Link to disease #)

Map position

Sequence

Accession

ID

Splice variants and their specific features

SLC37A1

SPX1

G3PP

Glycerol 3-phosphate (?)

E/Inorganic phosphate (?)

Adult bone marrow, colon, small intestine, kidney, liver and other tissues. Fetal liver, spleen and other tissues

 

21q22.3

NM_018964

 

Seven 5’ untranslated exons which form at least 4 different 5’ ends

SLC37A2

SPX2

Ci2

unknown

unknown

ESTs from several tissues

 

11q24.2

NM_198277

 

SLC37A3

SPX3

 

unknown

unknown

EST from several tissues, high level in breast and stomach

 

7q34

NM_032295

 

SLC37A4

SPX4

G6PT1

Glucose-6-phosphate

E/Inorganic phosphate

Strongly expressed in liver, kidney and hematopoietic progenitor cells

OMIM 232220/232240 Glycogen storage disease non-1a

11q23.3

NM_001467

Exon 7 is present in the brain-specific isoform (present also in skeletal muscle and heart)




References:

Original version of the SLC table:

Bartoloni L, Antonarakis SE. The human sugar-phosphate/phosphate exchanger family SLC37. Pflugers Arch. 2004 Feb;447(5):780-3.