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SLC36: The proton-coupled amino acid transporter family
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Human Gene
Name
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Protein
Name
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Aliases
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Predominant Substrates
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Transport type /Coupling ions *)
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Tissue distribution and cellular/ subcellular expression
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Link to disease #)
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Human gene locus
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Sequence
Accession
ID
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Splice variants and their specific features
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SLC36A1
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PAT1
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LYAAT1
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Gly, Ala, Pro, GABA, D-Ala, MeAIB
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C / H+
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Brain (neurons), intestine, colon,
kidney, lung, liver, spleen/
Lysosomes (neurons),
apical membrane (Caco-2 cells)
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-
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5q33.1
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NM_078483
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-
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SLC36A2
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PAT2
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Tramdorin1
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Gly, Ala, Pro
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C / H+
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Lung, heart, kidney, muscle, testis, spleen, adrenal gland,
thymus, sciatic nerve (Schwann cells)
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-
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5q33.1
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NM_181776
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-
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SLC36A3
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PAT3
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-
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-
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O
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-
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-
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5q33.1
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NM_181774
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-
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SLC36A4
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PAT4
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LYAAT2
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-
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O
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-
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-
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11q14.3
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NM_152313
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-
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