SLC35: The nucleoside-sugar transporter family
Human Gene
Name
Protein
Aliases
Predominant Substrates
Transport type /Coupling ions *)
Tissue distribution and cellular/ subcellular expression
Link to disease #)
Human gene locus
Sequence
Accession
ID
Splice variants and their specific features
SLC35A1
CMP-Sia transporter
CST
CMP-sialic acid
E/CMP
Ubiquitous/Golgi
6q16.1
NM_006416
SLC35A2
UDP-Gal transporter
UGT
UDP-galactose, UDP-N-acetylgalactosamine
E/UMP
Ubiquitous /Golgi
Xp11.23-p11.22
NM_005660
Two isoforms with different C-termini. hUGT1 and
hUGT2
SLC35A3
UDP-GlcNAc transporter
UGTrel2
UDP-N-acetylglucosamine
1p21
NM_012243
SLC35A4
UGTrel3
O
5q31.3
NM_080670
SLC35A5
UGTrel5
3q13.13
NM_017945
SLC35B1
UGTrel1
17q22
NM_005827
SLC35B2
UGTrel4
6p12.1-p11.2
NM_178148
SLC35B3
UGTrel6, CGI-19
6p24.3
NM_015948
SLC35B4
YEA4
7q33
NM_032826
SLC35C1
GDP-Fuc transporter
FUCT1
GDP-fucose
E/GMP
Leukocyte adhesion deficiency type II G/ Congenital disorder of glycosylation IIc G
11p11.11
NM_018389
Two alternative start sites of transcription.
D5-RNA encodes the 13 amino acids longer isoform at the N-termini.
SLC35C2
OVCOV1
20q13.12
NM_015945 NM_173073 NM_173179
SLC35D1
UGTrel7
UDP-glucuronic acid, UDP-N-acetylgalactosamine
E/
Ubiquitous /ER
1p31-p32
NM_015139 AB044343
SLC35D2
UGTrel8
9q22.32
NM_007001
N. Ishida, unpublished data
SLC35D3
6q23.3
NM_001008783
Deduced by comparison with a murine clone (AK018094).
SLC35E1
FLJ14251
19p13.11
NM_024881
SLC35E2
KIAA0447
1p36.32
NM_014854 NM_182838
SLC35E3
BLOV1
12q15
NM_018656