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SLC34: The
type II Na+-phosphate cotransporter family
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Human Gene
Name
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Protein
Name
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Aliases
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Predominant Substrates
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Transport type /Coupling ions *)
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Tissue distribution and cellular/ subcellular expression
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Link to disease #)
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Human gene locus
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Sequence
Accession
ID
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Splice variants and their specific features
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SLC34A1
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NaPi-lla
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NaPi-3
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inorganic
phosphate
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C / Na/HPO4=-
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kidney ( proximal tubules; apical)
osteoclasts, neurons
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G/XLH;
G/ ADHR
A/ OHO
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5q35
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NM_003052
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uncertain
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SLC34A2
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NaPi-llb
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inorganic
phosphate
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C / Na/HPO4=-
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small intestine, lung, testis, liver, secreting mammary gland
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4p15
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NM_006424
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unknown
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SLC34A3
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NaPi-llc
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inorganic
phosphate
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C / Na/HPO4=--
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Kidney (proximal tubules, apical)
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9q34
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NM_080877
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Unknown
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*)
C: Cotransporter
E: Exchanger
F: Facilitated transporter
O: Orphan transporter
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#)
A: Acquired defect
G: Genetic defect
P: Pseudogene
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