SLC30: The zinc efflux family

Human Gene Name

Protein Name

Aliases

Prominent substrate

Transport type

Distribution

Link to Disease

Human Gene Locus

Sequence Accession Number

SLC30A1

ZNT1

 

Zinc

Unknown

WidespreadA

Embryonic lethalB

1q32.3

NM_021194

SLC30A2

ZNT2

 

Zinc

Unknown

WidespreadA

 

1p35.3

NM_032513

SLC30A3

ZNT3

 

Zinc

Unknown

Glutamatergic neurons

Seizures,

AlzheimersB

2p23.3

NM_003459

SLC30A4

ZNT4

Dri27

Zinc

Unknown

WidespreadA

Secretory glands

Lethal milkB

15q21.1

NM_013309

SLC30A5

ZNT5

ZTL1

ZincD

Unknown

Widespread;

b cells

Bone abnormalities; heart failureB

5q13.1

NM_022902
NM_024055

SLC30A6

ZNT6

 

ZincD

Unknown

WidespreadA

 

2p22.3

NM_017964

SLC30A7

ZNT7

ZNTL2

Zinc

Unknown

WidespreadA

 

1p21.2

NM_133496

SLC30A8

ZNT8

 

Unknown

Unknown

Brain, Liver

 

8q24.11

NM_173851

SLC30A9C

ZNT9C

C4orf1

Unknown

Unknown

Unknown

 

4p13

NM_006345

SLC30A10 ZNT10           1q41

NM_018713

NP_001004433

A  By RNA analysis in rodents

B  In mouse

C  Orphan transporter

D  By association only, no zinc-dependent phenotypes described in mammalian cells




References:

Original version of the SLC table:

Palmiter RD, Huang L. Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers. Pflugers Arch. 2004 Feb;447(5):744-51.