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SLC29: The facilitative nucleoside transporter family
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Human Gene
Name
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Protein
Name
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Aliases
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Predominant Substrates
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Transport type /Coupling ions *)
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Tissue distribution and cellular/ subcellular expression
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Link to disease #)
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Human gene locus
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Sequence
Accession
ID
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Splice variants and their specific features
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SLC29A1
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ENT1
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Purine and pyrimidine nucleosides
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F
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Ubiquitous, plasma membrane (basolateral in polarised renal
epithelial cells) and perinuclear membranes
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6p21.1-p21.2
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NM_004955
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SLC29A2
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ENT2
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Purine and pyrimidine nucleosides and nucleobases
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F
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Ubiquitous, plasma membrane (basolateral in polarised renal
epithelial cells). Particularly abundant in skeletal muscle
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11q13
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NM_001532
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HNP36: exon 4 splice variant leading to N- terminal truncation
and lack of transport function.
hENT2A: exon 9 splice variant leading to C-terminal truncation
and lack of transport function
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SLC29A3
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ENT3
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Purine and pyrimidine nucleosides and some nucleobases
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not determined
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Widely distributed, possibly intracellular
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10q22.1
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NM_018344
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SLC29A4
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ENT4
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Adenosine
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not determined
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Widely distributed
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7p22
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NM_153247
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*)
C: Cotransporter
E: Exchanger
F: Facilitated transporter
O: Orphan transporter
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#)
A: Acquired defect
G: Genetic defect
P: Pseudogene
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