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SLC28: The Na+-coupled nucleoside transport family
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Human Gene
Name
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Protein
Name
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Aliases
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Predominant Substrates
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Transport type /Coupling ions *)
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Tissue distribution and cellular/ subcellular expression
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Link to disease #)
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Human gene locus
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Sequence
Accession
ID
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Splice variants and their specific features
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SLC28A1
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CNT1
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Pyrimidine nucleosides, adenosine
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C / Na+ / pyrimidine nucleosides
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Liver, kidney, small intestine,
(epithelia apical membrane)
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15q25-q26
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Additional 116 bp in the 5’ untranslated
region; obtained from human fetal liver cDNA library; unknown
function
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SLC28A2
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CNT2
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SPNT
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Purine nucleosides, uridine
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C / Na+ / purine nucleosides
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Kidney (apical membrane), liver, heart, brain, placenta,
pancreas, skeletal muscle, colon, rectum, small intestine
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15q15
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NM_004212
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SLC28A3
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CNT3
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Broadly selective for pyrimidines and purines
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C / 2Na+ / pyrimidine and purine nucleosides
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Pancreas, trachea, bone marrow, and mammary gland, intestine,
lung, placenta, prostrate, testis, and liver
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9q22.2
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*)
C: Cotransporter
E: Exchanger
F: Facilitated transporter
O: Orphan transporter
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#)
A: Acquired defect
G: Genetic defect
P: Pseudogene
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