|
SLC26: The multifunctional anion exchanger
family
|
| Human Gene Name |
Aliases |
Reported
substrates
|
Tissue
Distribution
|
Disease association(s) |
Human Gene Locus |
Sequence Accession ID |
|
SLC26A1
|
Sat-1
|
SO42-, oxalate
|
liver, kidney
|
|
4p16.3
|
NM_022042
NM_213613
NM_134425
|
|
SLC26A2
|
DTDST
|
SO42-, Cl-
|
widespread
|
Chondrodysplasias
|
5q31-34
|
NM_000112
|
|
SLC26A3
|
DRA, CLD
|
SO42-, Cl-,
HCO3-, OH-,
oxalate
|
intestine, sweat gland, pancreas, prostate
|
Congenital Chloride-losing Diarrhea
|
7q31
|
NM_000111 |
|
SLC26A4
|
pendrin
|
Cl-, HCO3-, I-,
formate
|
inner ear, kidney,
thyroid
|
Pendred syndrome
Deafness (DFNB4)
|
7q31
|
NM_000441
|
|
SLC26A5
|
prestin
|
?
|
inner ear
|
Deafness?
|
7q22
|
NM_198999 |
|
SLC26A6
|
CFEX, PAT-1
|
SO42-, Cl-,
HCO3-, OH-,
oxalate, formate
|
widespread
|
|
3p21
|
NM_022911
NM_134263
NM_134426 |
|
SLC26A7
|
none
|
SO42-, Cl-,
oxalate
|
kidney
|
|
8q22.2
|
NM_052832
NM_134266 |
|
SLC26A8
|
Tat1
|
SO42-, Cl-,
oxalate
|
sperm, brain
|
|
6p21.3
|
NM_052961
NM_138718
|
|
SLC26A9
|
none
|
SO42-, Cl-,
oxalate
|
lung
|
|
1q32
|
NM_052934
NM_134325 |
| SLC26A10 |
none |
pseudogene |
|
|
12q13 |
NM_133489
NM_001018084
|
|
SLC26A11
|
none
|
SO42-
|
widespread
|
|
17q25
|
NM_173626 |
|