SLC26: The multifunctional anion exchanger family

Human Gene Name Aliases

Reported
substrates

Tissue
Distribution

Disease association(s)

Human Gene Locus

Sequence Accession ID

SLC26A1

Sat-1

SO42-, oxalate

liver, kidney

 

4p16.3

NM_022042

NM_213613

NM_134425

SLC26A2

DTDST

SO42-, Cl-

widespread

Chondrodysplasias

5q31-34

NM_000112

 

SLC26A3

DRA, CLD

SO42-, Cl-, HCO3-, OH-, oxalate

intestine, sweat gland, pancreas, prostate

Congenital Chloride-losing Diarrhea

7q31

NM_000111

SLC26A4

 

pendrin

Cl-, HCO3-, I-, formate

inner ear, kidney,

thyroid

Pendred syndrome

Deafness (DFNB4)

7q31

NM_000441

 

SLC26A5

prestin

?

inner ear

Deafness?

7q22

NM_198999

SLC26A6

CFEX, PAT-1

SO42-, Cl-, HCO3-, OH-, oxalate, formate

widespread

 

3p21

NM_022911
NM_134263
NM_134426

SLC26A7

none

SO42-, Cl-, oxalate

kidney

 

8q22.2

NM_052832
NM_134266

SLC26A8

Tat1

SO42-, Cl-, oxalate

sperm, brain

 

6p21.3

NM_052961
NM_138718

SLC26A9

none

SO42-, Cl-, oxalate

lung

 

1q32

NM_052934
NM_134325
SLC26A10 none pseudogene     12q13 NM_133489

NM_001018084

SLC26A11

none

SO42-

widespread

 

17q25

NM_173626




References:

Original version of the SLC table:

Mount DB, Romero MF. The SLC26 gene family of multifunctional anion exchangers. Pflugers Arch. 2004 Feb;447(5):710-21.


Chambard JM, Ashmore JF. Sugar transport by mammalian members of the SLC26 superfamily of anion-bicarbonate exchangers. J Physiol. 2003 Aug 1;550(Pt 3):667-77.