SLC24: The Na+/(Ca2+-K+) exchanger family

SLC24: The Na+/(Ca+2+-K+) exchanger family
Human Gene Name	Protein Name	Aliases	Predominant Substrates	Transport type/ Coupling ions ^*)	Tissue distribution and cellular/subcellular expression	Link to disease	Human gene locus	Sequence Accession ID	Splice variants and their specific features
SLC24A1	NCKX1		Na⁺,Ca²⁺, K⁺	E/4Na⁺/Ca²⁺-K⁺	rod photoreceptors, platelets		15q22	NM_004727	several splice variants, function unknown
SLC24A2	NCKX2		Na⁺,Ca²⁺, K⁺	E/4Na⁺/Ca²⁺-K⁺	brain, retinal cone photoreceptors, retinal ganglion cells		9p22	NM_020344
SLC24A3	NCKX3		Na⁺,Ca²⁺, K⁺	E/Na⁺/Ca²⁺-K⁺	brain, aorta, uterus, intestine		20p11	NM_020689	two splice variants, function unknown
SLC24A4	NCKX4		Na⁺,Ca²⁺, K⁺	E/Na⁺/Ca²⁺-K⁺	brain, aorta, lung, thymus		14q32	NM_153646
SLC24A5	NCKX5						15q21.1	NM_205850	three splice variants, function unknown
SLC24A6	NCKX6	FLJ22233					12q24.13	NM_024959
^*) E: Exchanger

References:

Original version of the SLC table:

Schnetkamp PP. The SLC24 Na(+)/Ca(2+)-K(+) exchanger family: vision and beyond. Pflugers Arch. 2004 Feb;447(5):683-8.