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SLC23: The Na+-dependent
ascorbic acid transporter family
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Human Gene
Name
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Protein
Name
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Aliases
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Predominant Substrates
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Transport type /Coupling ions*
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Tissue distribution and cellular/ subcellular expression
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Link to disease#
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Human gene locus
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Sequence
Accession
ID
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Splice variants and their specific features
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SLC23A1
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SVCT1
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YSPL3
NCBT2
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L-Ascorbic acid
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C / Na+
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Epithelial tissues including kidney, intestines, liver, ovary, prostate, and thymus,
and in B-lymphocytes.
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5q31.2-q31.3
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NM_005847
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Intestine additionally expresses a non-functional splice variant, and a
9-kb transcript is specific to thymus
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SLC23A2
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SVCT2
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YSPL2
KIAA0238
NBTL1
NCBT1
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L-Ascorbic acid
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C / Na+
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Widespread including brain (neurons), retina,
placenta, spleen, prostate, testis, ovary, (rat SVCT2 also in lung,
adrenal, osteoblast)
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20p12.2-12.3
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NM_005116
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SLC23A3
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SVCT3
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YSPL1
FLJ31168
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2q35
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NM_144712
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FLJ31168 (a partial sequence) may be a splice variant
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SLC23A4
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SVCT4
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7q33
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XM_069843
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§The HUGO gene names for SVCT1
and SVCT2 were reassigned in 2003.
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