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SLC22: The organic cation/anion/zwitterion transporter
family
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|
Human Gene
Name
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Protein
Name
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Aliases
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Predominant Substrates
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Transport type/Coup- ling ions
*)
|
Tissue distribution and cellular/ subcellular expression
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Link to disease #)
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Human gene locus**
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Sequence
Accession
ID
|
Splice variants and their specific features
|
|
SLC22A1
|
hOCT1
|
|
Organic cations, polyspecific
|
F
|
Liver, sinusoidal membrane
of hepatocytes
|
|
6q26
|
NM_003057
|
3 splice variants from liver with no uptake in vitro [29]
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|
SLC22A2
|
hOCT2
|
|
Organic cations, polyspecific
|
F
|
Kidney, basolateral membrane of proximal tubules; brain, neurons
|
|
6q26
|
NM_003058
|
hOCT2-A from kidney with uptake in vitro,
( AB075951)
|
|
SLC22A3
|
hOCT3
|
hEMT
|
Organic cations, polyspecific
|
F
|
Liver, skeletal muscle, placenta, kidney, heart, lung, brain
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|
6q26-27
|
NM_021977
|
|
|
SLC22A4
|
hOCTN1
|
|
Organic cations,
polyspecific
|
F or E/H+
|
Kidney, skeletal muscle, placenta, prostate, heart
|
|
5q23.3
|
NM_003059
|
|
|
SLC22A5
|
hOCTN2
|
CT1
|
L-carnitine,
organic cations, polyspecific
|
C/Na+
and L-carnitine,
F
(for organic cations)
|
Skeletal muscle, kidney (luminal membrane of proximal tubules),
prostate, lung, pancreas, heart, small intestine, adrenal gland, thyroid gland, liver etc.
|
Primary systemic carnitine deficiencyG
|
5q23.3
|
NM_003060
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|
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SLC22A6
|
hOAT1
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|
Organic anions, polyspecific
|
E/organic anions
|
Kidney, basolateral membrane of proximal tubules; placenta,
brain
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11q12.3
|
NM_004790
|
hOAT1-1 from kidney with uptake in vitro, (AB009697),
2 further variants with no uptake in vitro [4]
|
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SLC22A7
|
hOAT2
|
|
Organic anions, polyspecific
|
F or E
|
Liver, sinusoidal membrane of hepatocytes; kidney, basolateral
membrane of proximal tubules
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6q21.1-2
|
NM_006672
|
Kidney and liver specific splice variants with no uptake
in vitro [4]
|
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SLC22A8
|
hOAT3
|
|
Organic anions, polyspecific
|
E/organic anions
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Kidney, basolateral membrane of proximal tubules; brain,
luminal membrane of choroid plexus; skeletal muscle, developing
bone
|
Osteoscle-rosis/oste-opetrosis
in miceG
|
11q12.3
|
NM_004254
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|
|
SLC22A9
|
hUST3
|
|
not determined
|
O
|
Liver
|
|
11q12.3
|
NM_080866
|
|
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SLC22A10
|
hOAT5
|
|
not determined
|
O
|
Liver
|
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11q12.3
|
AP003420
|
|
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SLC22A11
|
hOAT4
|
|
Organic anions, polyspecific
|
F or E
|
Kidney, luminal membrane of proximal tubules, placenta
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11q13.1
|
NM_018484
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SLC22A12
|
hURAT1
|
|
Urate
|
E/organic anions
|
Kidney
|
Idiopathic renal hypo-uricaemiaG
|
11q13.1
|
NM_144585
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|
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SLC22A13
|
OCTL1
|
hORCTL3
|
not determined
|
O
|
Kidney, colon, small intestine
|
|
3p22.2
|
NM_004256
|
|
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SLC22A14
|
OCTL2
|
hORCTL4
|
not determined
|
O
|
Kidney, colon, small intestine
|
|
3p22.2
|
NM_004803
|
|
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SLC22A15
|
FLIPT1
|
|
not determined
|
O
|
Kidney, brain, liver, skeletal muscle, heart, placenta, lung,
spleen
|
|
1p13.1
|
NM_018420
|
|
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SLC22A16
|
hCT2
|
hFLIPT2 hOCT6
|
Carnitine
|
F
|
Testis, Sertoli cells and epididymdal duct cells, bone marrow,
leukocytes, kidney
|
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6q21-22.1
|
NM_033125
|
|
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SLC22A17
|
BOIT
|
BOCT
|
not
determined
|
O
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Brain
|
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14q11.2
|
NM_016609
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|
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SLC22A18?
(SLC22A1L)
|
|
HET, ITM, BWR1A, IMPT1, TSSC5, ORCTL2, BWSCR1A, p45-BWR1A
|
not
determined (transport of chloroquine- and quinidine-related
compounds?)
|
|
tumor suppressing gene
|
Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma,
adrenocortical carcinoma, and lung, ovarian, and breast cancerG
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11p15.5
|
NM_002555
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*)
C: Cotransporter
E: Exchanger
F: Facilitated transporter
O: Orphan transporter
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#)
A: Acquired defect
G: Genetic defect
**Gene loci were corrected according to [15]
P: Pseudogene
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