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SLC21/SLCO: The organic anion
transporting family
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New Gene Symbol 1)
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New Protein Name1)
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Old Gene Symbol
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Old Protein Names
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Predominant Substrate
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Tissue distribution and cellular/subcellular
expression
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Gene Locus2)
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Sequence Accession ID
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Splice Variant
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Slco1a1
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Oatp1a1
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Slc21a1
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Oatp1, Oatp
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Bile salts, organic anions, organic cations
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Liver (basolateral membrane of hepatocytes),
kidney (apical membrane of proximal tubule), choroid plexus (apical)
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4q44 (r)
6A3-A5 (m)
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NM_017111
NM_013797
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SLCO1A2
slco1a2
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OATP1A2
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SLC21A3
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OATP-A, OATP
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Bile salts, organic anions, organic cations
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12p12 (h)
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NM_021094
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Slco1a3
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Oatp1a3_v1
Oatp1a3_v2
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Slc21a4
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OAT-K1
OAT-K2
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Bile salts, organic anions
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Kidney
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4q44 (r)
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NM_030837
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AB012662
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Slco1a4
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Oatp1a4
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Slc21a5
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Oatp2
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Digoxin, bile salts, organic anions, organic
cations
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Liver, blood-brain barrier, choroid plexus,
ciliary body, retina
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4 (r)
6G2 (m)
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NM_131906
NM_030687
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Slco1a5
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Oatp1a5
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Slc21a7
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Oatp3
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Bile salts, organic anions
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Jejunum, choroid plexus
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4q44 (r)
6G2 (m)
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NM_030838
NM_130861
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Slco1a6
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Oatp1a6
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Slc21a13
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Oatp5
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4q44 (r)
6G2 (m)
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NM_130736
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SLCO1B1
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OATP1B1
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SLC21A6
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OATP-C, LST-1, OATP2
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Bile salts, organic anions
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Liver
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12p12 (h)
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NM_006446
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Slco1b2
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Oatp1b2
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Slc21a10
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Oatp4. Lst-1
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Bile salts, organic anions
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Liver, ciliary body
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4q44 (r)
6G2 (m)
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NM_031650
NM_020495
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OATP1B3
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SLC21A8
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OATP8
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Bile salts, organic anions, digoxin
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Liver, cancer cell lines
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12p12 (h)
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NM_019844
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SLCO1C1
Slco1c1
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OATP1C1
Oatp1c1
Oatp1c1
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SLC21A14
Slc21a14
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OATP-F, OATP-RP5
Oatp14, BSAT1, Oatp2
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T4, rT3, BSP
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Brain, testis (Leydig cells)
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12p12 (h)
4q44 (r)
6G1 (m)
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NM_017435
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SLCO2A1
Slco2a1
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OATP2A1
Oatp2a1
Oatp2a1
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SLC21A2
Slc21a2
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hPGT
rPGT
mPGT
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Eicosanoids
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Ubiquitous
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3q21 (h)
8q32 (r)
9F1 (m)
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NM_005630
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SLCO2B1
Slco2b1
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OATP2B1
Oatp2b1
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SLC21A9
Slc21a9
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OATP-B, OATP-RP2
Oatp9. moat1
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E-3-S, DHEAS, BSP
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Liver, placenta, ciliary body
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11q13 (h)
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NM_007256
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SLCO3A1
Slco3a1
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OATP3A1
Oatp3a1
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SLC21A11
Slc21a11
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OATP-D, OATP-RP3
Oatp11, MJAM
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E-3-S, prostaglandin
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Ubiquitously
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15q26 (h)
7D1 (m)
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NM_013272
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BC000585
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SLCO4A1
Slco4a1
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OATP4A1
Oatp4a1
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SLC21A12
Slc21a12
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OATP-E, OATP-RP1
Oatp12, oatpE
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Taurocholate, T3, prostaglandin
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Ubiquitously
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20q13.1 (h)
2H4 (m)
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NM_016354
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SLCO4C1
slc04c1
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OATP4C1
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SLC21A20
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OATP-H
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Kidney
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5q21 (h)
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NM_180991
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SLCO5A1
slc05a1
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OATP5A1
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SLC21A15
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OATP-J, OATP-RP4
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8q13.1 (h)
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NM_030958
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SLCO6A1
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OATP6A1
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SLC21A19
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OATP-I, GST
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Testis
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5q21 (h)
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NM_173488
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Slco6b1
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Oatp6b1
Oatp6b1
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Slc21a16
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Oatp16, TST-1, GST-1
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Taurocholate, T3, T4,
DHEAS
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Testis, epididymis, ovary, adrenal gland
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9 (r)
1 (m)
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NM_133412
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Slco6c1
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Oatp6c1
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Slc21a18
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Oatp18, TST-2, GST-2
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Taurocholate, T3, T4,
DHEAS
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Testis
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9 (r)
1 (m)
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NM_173338
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Slco6d1
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Oatp6d1
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Slc21a17
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Oatp17
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1 (m)
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AK014872
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1) All capital symbols denote human genes and gene
products while lower case/italics symbols stand for rodent genes and gene
products (exception: OAT-K1 is a
rat protein). To better discriminate between human, rat and mouse gene products
sometimes a lower case h, r or m preceeds the abbreviation. However, this
is not part of the gene or protein symbol.2) (h) human, (r) rat, (m) mouse
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