SLC20: The type III Na+-phosphate cotransporter family

Human Gene

Name

Protein

Name

Aliases

Predominant Substrates

Transport type /Coupling ions *)

Tissue distribution and cellular/ subcellular expression

 

Link to disease #)

Human gene locus

Sequence

Accession

ID

Splice variants

SLC20A1

PiT-1

Gibbon ape leukemia virus receptor 1; GLVR1; Glvr-1

Pi, Na+

C/ Na+/ Pi

Widely expressed- highest in bone marrow; likely expressed on basolateral membranes of` polarized epithelia

 

2q11-q14

NM_005415

 

SLC20A1P1

 

 

 

 

 

 

14

NG_002534

 

SLC20A2

PiT-2 

Amphotropic murine leukemia virus receptor; Gibbon ape leukemia virus receptor 2; GLVR2; Glvr-2; MLVAR

Pi, Na+

C/ Na+/ Pi

Widely expressed- highest in heart; likely expressed on basolateral membranes of polarized epithelia

 

8p12-q21

NM_006749

 

*)
C: Cotransporter
E: Exchanger
F: Facilitated transporter
O: Orphan transporter

#)
A: Acquired defect
G: Genetic defect
P: Pseudogene

 




References:

Original version of the SLC table:

Collins JF, Bai L, Ghishan FK. The SLC20 family of proteins: dual functions as sodium-phosphate cotransporters and viral receptors. Pflugers Arch. 2004 Feb;447(5):647-52.