|
Human
Gene
Name
|
Protein
Name
|
Aliases
|
Predominant
Substrates
|
Transport
type /Coupling ions
|
Tissue
distribution and cellular/ subcellular expression
|
Link
to disease
|
Human
gene locus
|
Sequence
Ac-
cession
ID
|
Splice
variants and their specific features
|
|
SLC18A1
|
VMAT1
|
CGAT
VAT1
|
5HT
Dopamine
Adrenaline
Noradrenaline
Histamine
|
E
/ H+
|
Adrenal
gland (medulla), sympathetic ganglia (SIF-cells), carotid body,
skin (Merkel cells), GI tract (EC cells)
Subcellular:
large dense-core vesicles
|
|
8p21.3
|
NM
_003053
|
|
|
SLC18A2
|
VMAT2
|
SVAT
SVMT
VAT2
(MAT)
|
5HT
Dopamine
Adrenaline
Noradrenaline
Histamine
|
E
/ H+
|
Brain
(neurons), adrenal gland (medulla), sympathetic ganglia (neurons,
SIF cells), carotid body, small and large intestine (neurons),
stomach (neurons and ECL-cells), endocrine pancreas, basophils,
mast cells, dendritic cells and platelets
Subcellular:
large dense-core vesicles, smallll dense-core vesicles, tuberovesicular
structures and small synaptic (dopaminergic) vesicles.
|
Cardio-vascular,
Drug
Addiction
[42]
|
10q24.3-q25.1
|
NM
_003054
|
|
|
SLC18A3
|
VAChT
|
|
Acetylcholine
|
E
/ H+
|
Brain
(neurons), peripheral nervous system (neurons), intestine (neurons)
Subcellular:
small synaptic vesicles
|
Myasthenic
syndromes (ChAT only) [9]
|
10q11.2
|
NM
_003055
|
R-type
(minor
variant)
V-type
(major variant)
|
