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SLC17: The vesicular glutamate transporter family
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Human Gene
Name
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Protein
Name
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Aliases
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Predominant Substrates
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Transport type /Coupling ions *)
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Tissue distribution and cellular/ subcellular expression
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Link to disease #)
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Human gene locus
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Sequence
Accession
ID
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Splice variants and their specific features
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SLC17A1
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NPT1
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NaPi1
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organic acids
Phosphate
chloride
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unknown
Na+
channel
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kidney, liver
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6p21.3-p23
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NM_005074
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a, b,c
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SLC17A2
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NPT3
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unknown
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Heart, muscle,
Brain, placenta, lung, liver kidney, pancreas
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6p21.3-p23
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NM_005835
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SLC17A3
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NPT4
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unknown
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liver, kidney
Small intestine, testis
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6p21.3-p23
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NM_006632
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SLC17A4
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Na+/PO4--cotransporter homologue
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unknown
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Small intestine, colon, liver, pancreas
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6p21.3-p23
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NM_005495
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SLC17A5
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sialin
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AST
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Sialic acid
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C/ H+
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Heart, brain, liver, lung, pancreas, placenta, muscle, uterus,
bladder, kidney, spleen.
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Sialic acid storage disease
(Salla disease) G
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6q14-q15
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NM_012434
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SLC17A6
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vglut2
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DNPI
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glutamate
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E / H+
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Brain (neurons only), endocine
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11p14.3
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NM_020346
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SLC17A7
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vglut1
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BNPI
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glutamate
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E / H+
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Brain (neurons only), endocrine
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19q13
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NM_020309
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SLC17A8
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Vglut3
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glutamate
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E / H+
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Brain (neurons and glia), liver, kidney
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12q23.2
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NM_139319
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