|
SLC15: The proton oligopeptide cotransporter
family
|
|
Human Gene
Name
|
Protein
Name
|
|
Predominant Substrates
|
Transport type /Coupling ions *)
|
Tissue distribution and cellular/ subcellular
expression
|
Link to disease #)
|
Human gene locus
|
Sequence
Accession
ID
|
Splice variants and their
specific features
|
|
SLC15A1
|
PEPT1
|
Oligopeptide
transporter 1,
H+/peptide transporter 1
|
Di-, and
tripeptides
protons
|
C / H+
|
Intestine, kidney
apical, lysosomal membrane
|
none
|
13q33-q34
|
NM_005073
|
hPEPT1-RF
shift of pH
sensitivity
profile
|
|
SLC15A2
|
PEPT2 |
Oligopeptide
transporter 2,
H+/peptide transporter 2 |
Di-, and
tripeptides
protons |
C / H+ |
Kidney, lung, brain, mammary gland, bronchial epithelium |
none |
3q13.3-q21 |
NM_021082 |
|
| SLC15A3 |
PHT2
hPTR3 |
Peptide/histidine transporter 2,
human peptide transporter 3 |
Histidine,
di- and tripeptides,
protons |
C / H+ |
Lung, spleen, thymus (faintly in brain, liver, adrenal gland, heart) |
none |
11q12.1 |
NM_016582 |
multiple features unknown |
|
SLC15A4
|
PHT1
PTR4
|
Peptide/histidine
transporter 1,
peptide transporter 4
|
Histidine,
di- and tripeptides
protons
|
C / H+
|
Brain, retina, placenta
|
none
|
12q24.32
|
NM_145648
|
multiple,
features unknown
|
|
*) C: Cotransporter
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