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SLC14: The urea transporter family |
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Human Gene Name |
Protein Name |
Aliases |
Predominant Substrates |
Transport type / Coupling ions |
Tissue distribution and cellular / subcellular expression |
Link to disease |
Human gene locus |
Sequence Accession ID |
Splice variants and their specific features |
UT-B1(43) |
UT3 JK Kidd UT11 |
Urea |
F / - |
- Kidney (vasa recta, papillary epithelia) - Erythrocytes, testes, brain, spleen |
Kidd antigen blood group G |
18q11.1-18q11.2 | UT-B1b (alternated 3'UTR) | ||
UT-A1 (97, 117) |
UT1 | Urea |
F / - |
- Kidney (luminal membrane of inner medullary collecting duct, IMCD) |
Orthostatic hypotension G (?) |
18q12.1-18q21.1 |
UT-A1b (alternated 3'UTR) |
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UT-A2(55) |
UT2 |
Urea |
F / - |
- Kidney (descending thin limb of loops of Henle) - Liver, heart |
UT-A2b (alternated 3'UTR) |
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UT-A3 (44, 67) |
UT4 |
Urea |
F / - |
- Kidney (luminal membrane of IMCD) - Colon |
[rat] |
UT-A3b (alternated 3'UTR) |
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UT-A4(43) |
Urea |
F / - |
- Kidney medulla [rat] |
[rat] |
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UT-A5 |
Urea |
F / - |
- Testis [mouse] |
[mouse] |
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1.Link to
disease 2.Kidd antigen blood groupG 3. Orthostatic hypotensionG (?) |
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References: |