SLC14: The urea transporter family

Human Gene

Name

Protein

Name

Aliases

Predominant Substrates

Transport type / Coupling ions

Tissue distribution and cellular / subcellular expression

 

Link to disease

Human gene locus

Sequence

Accession

ID

Splice variants and their specific features

SLC14A1

UT-B1(43)

UT3

JK

Kidd

UT11

Urea

F / -

- Kidney (vasa recta, papillary epithelia)

- Erythrocytes, testes, brain, spleen

Kidd antigen blood group G

18q11.1-18q11.2

NM_015865

UT-B1b (alternated 3'UTR)

SLC14A2

UT-A1 (97, 117)

UT1

Urea

F / -

- Kidney (luminal membrane of inner medullary collecting duct, IMCD)

Orthostatic hypotension G (?)

18q12.1-18q21.1

AF349446

UT-A1b (alternated 3'UTR)

 

UT-A2(55)

UT2

Urea

F / -

- Kidney (descending thin limb of loops of Henle)

- Liver, heart

 

NM_007163

UT-A2b (alternated 3'UTR)

 

UT-A3 (44, 67)

UT4

Urea

F / -

- Kidney (luminal membrane of IMCD)

- Colon

 

AF041788

[rat]

UT-A3b (alternated 3'UTR)

 

UT-A4(43)

 

Urea

F / -

- Kidney medulla [rat]

 

AF042167

[rat]

 
 

UT-A5

 

Urea

F / -

- Testis [mouse]

 

AF258601

[mouse]

 

 

1.Link to disease 2.Kidd antigen blood groupG 3. Orthostatic hypotensionG (?)


References:

Original version of the SLC table:

Shayakul C, Hediger MA. The SLC14 gene family of urea transporters. Pflugers Arch. 2004 Feb;447(5):603-9.