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SLC13: The human Na+-sulfate/carboxylate
cotransporter family
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Human Gene
Name
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New Protein
Name
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Former Protein
Name&
Aliases
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Predominant Substrates
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Transport type /Coupling ions *)
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Tissue distribution and cellular/ subcellular expression
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Link to disease
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Human gene locus
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Sequence
Accession
ID
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Number of transcripts and splice variants and their specific
features
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SLC13A1
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NaS1
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NaSi-1, Na-sulfate
|
Sulfate, selenate, thiosulfate
|
C / Na+ / SO42- / S2O3
/ SeO42-
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Kidney, proximal tubular cells, brush border membrane
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None
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7q31-q32
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NM_022444
|
2.2kb & 2.7kb transcripts (both functional, with a 3’
UTR 0.5kb longer variant)
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SLC13A2
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NaC1
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NaDC-1, SDCT1, NaDC-2
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Succinate, citrate, a-keto glutarate
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C / Na+ / succinate/
citrate /
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Kidney, intestine, brush border membrane
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None
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17p11.1-q11.1
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NM_003984
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One 2.8kb transcript only
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SLC13A3
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NaC2
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NaDC-3, SDCT2
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Succinate, citrate, a-keto glutarate
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C / Na+ / succinate/
citrate /
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Kidney proximal tubule basolateral membrane, liver, pancreas, brain, placenta
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None
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20q12-q13.1
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NM_022829
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One 3.6kb transcript only
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SLC13A4
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NaS2
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SUT-1
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Sulfate
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C / Na+ / SO42-
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Placenta, tonsillar high endothelial venules, testis, heart
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None
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7q33
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NM_012450
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2.9kb (functional) and 4.5kb (function unknown) transcripts
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SLC13A5
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NaC3
|
NaCT
|
Citrate
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C / Na+ /
citrate / succinate/ pyruvate
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Liver, brain, testis
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None
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12p12-13
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NM_177550
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One 3.2kb transcript only
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