SLC11: The proton coupled metal ion transporter family
Human Gene Name	Protein Name	Aliases	Predominant Substrates	Transport type /Coupling ions*	Tissue distribution and cellular/ subcellular expression	Link to disease#	Human gene locus	Sequence Accession ID	Splice variants and their specific features
SLC11A1	NRAMP1	NRAMP LSH	Mn^2+, Fe^2+, and other divalent metal ions	C / H^+	Phagolysosomes of phagocytes (macrophages, neutrophils)	Polymorphisms linked to susceptibility^G to bacterial infections (e.g. tuberculosis, leprosy), and to autoimmune diseases (e.g. Crohn’s disease)	2q35	NM_000578
SLC11A2	DMT1	NRAMP2 DCT1	Fe^2+, Cd^2+, Co^2+, Cu^1+, Mn^2+	C / H^+	Widespread, including intestine, erythroid cells, kidney, lung, brain, testis (Sertoli cells), thymus	Hereditary hemochromatosis^A	12q13	NM_000617	Multiple splice forms (from 1A or 1B exons at 5′ end, and with or without the 3′ iron-responsive element) are discretely distributed and may be subject to separate control mechanisms
*) C: Cotransporter #)G: Genetic defect A: Acquired defect (due to genetic defects in the HFE gene) §IREG1 (also known as Ferroportin-1, MTP1, or FPN1) was previously assigned to SLC11A3. However, IREG1 bears no significant homology with SLC11A1 and SLC11A2, and has been therefore reassigned to SLC40A1.

References:

Original version of the SLC table:

Mackenzie B, Hediger MA. SLC11 family of H(+)-coupled metal-ion transporters NRAMP1 and DMT1. Pflugers Arch. 2004 Feb;447(5):571-9.