SLC10: The sodium bile salt cotransport family

Human

Gene

Name

Protein

Name

Aliases

Predominant Substrates

Transporter type

/Coupling ions

Tissue distribution and cellular/ subcellular expression

Link to

Disease

(OMIM)

Human

gene locus

Sequence

Accession

ID

Splice variants and their specific features

 

SLC10A1

 

NTCP

 

LBAT

 

Bile acids

 

C / Na+

 

Liver, pancreas

 

 

 

14q24.1

 

NM_003049

 

Ntcp1 / Ntcp2

(mouse)

 

SLC10A2

 

ASBT

 

IBAT,

ISBT,

 

Bile acids

 

C / Na+

 

Ileum, kidney, biliary

tract

 

PBAM

(601295)

 

13q33

 

NM_000452

 

tASBT (rat)

 

SLC10A3

P3

 

 

O

Ubiquitously (based on EST data)

 

Xq28

NM_019848

 

 

SLC10A4

P4

 

 

O

Brain neuroblastoma (based on EST data)

 

4p11

NM_152679

 

SLC10A5 P5     O Fetal brain (based on EST data)   8q21 NM_001010893  

SLC10A6

P6

SOAT 

estrone-3-sulftate, dehydroepiandroster-one sulfate

C / Na+

Heart, lung, liver, spleen, testis, adrenal gland, small intestine, colon, placenta

 

4q21.3

NM_197965

 




References:

Original version of the SLC table:

Hagenbuch B, Dawson P. The sodium bile salt cotransport family SLC10. Pflugers Arch. 2004 Feb;447(5):566-70.