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SLC9: The Na+/ H+ exchanger family
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Human Gene
Name
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Protein
Name
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Aliases
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Substrate
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Transport type /Coupling ions *)
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Tissue distribution and cellular/ subcellular expression
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Link to disease #)
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Human gene locus
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Sequence
Accession
ID
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Splice variants and their specific features
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SLC9A1
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NHE1
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APNH
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Na+, H+, Li+, NH4+
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E: Na+ / H+ (1:1)
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Ubiquitous
(plasma membrane; basolateral surface of epithelia)
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Ischemia / reperfusion injuriesA;
Essential hypertensionA;
Diabetes-associated vascular
hypertrophyA
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1p36.1-p35
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NM_003047
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SLC9A2
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NHE2
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Na+, H+,
Li+, NH4+
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E: Na+ / H+
(1:1)
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Stomach, intestinal tract >
skeletal muscle
>>> kidney, brain, uterus,
testis >> heart, lung;
(plasma membrane; apical surface
of epithelia)
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2q11.2
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NM_003048
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SLC9A2L
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Xq13.3
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XM_066494
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limited homology in C-terminus.
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SLC9A3
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NHE3
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Na+, H+,
Li+, NH4+
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E: Na+ / H+
(1:1)
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Intestinal tract, stomach >
kidney, gall bladder, epididymis, >>>> brain;
(apical surface and recycling
endosomes of epithelia)
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Congenital secretory diarrhea
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5p15.3
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NM_004174
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SLC9A3P
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10q21.1
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XM_171384
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pseudogene
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SLC9A3P2
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22q11.21
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NG_005203
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pseudogene
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| SLC9A3R1 |
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NHERF, EBP50 |
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17q24.3-17q25 |
NM_004252 |
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| SLC9A3R2 |
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SIP-1, TKA-1, NHERF-2, E3KARP |
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16p13.3 |
NM_004785 |
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SLC9A4
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NHE4
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Na+, H+
Li+ ?
NH4+ ?
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E: Na+ / H+
(1:1)
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Stomach >>>> kidney, brain;
(plasma membrane; basolateral
membrane of epithelia)
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2q11-q12
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NM_001011552
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partial mRNA
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SLC9A5
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NHE5
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Na+, H+,
Li+,
NH4+ ?
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E: Na+ / H+
(1:1)
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Brain (neurons);
(plasma membrane and recycling
endosomes/synaptic vesicles)
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16q22.1
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NM_004594
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SLC9A6
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NHE6
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KIAA0267
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?
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E: ?
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Ubiquitous;
(recycling endosomes)
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Xq26.3
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NM_006359
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NHE6_v1
NHE6_v2
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SLC9A7
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NHE7
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Na+, K+,
H+, Li+,
NH4+ ?
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E: Na+ (K+) / H+
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Ubiquitous;
(trans-Golgi network and endosomes)
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Xp11.3
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NM_032591
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SLC9A7P1
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12q23.1
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XM_062645
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partially processed pre-mRNA
pseudogene
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SLC9A7P2
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3q24
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XM_067158
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very limited homology;
pseudogene?
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SLC9A8
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NHE8
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KIAA0939
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?
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E: ?
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Ubiquitous;
(plasma membrane and possibly
other endomembrane compartments)
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20q13
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NM_015266
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| SLC9A9 |
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3q23-q24 |
NM_173653 |
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| SLC9A10 |
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3q13.2 |
NM_183061 |
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SLC9A11
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MGC43026
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1q25.1
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NM_178527
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*) C: Cotransporter
E: Exchanger
F: Facilitated transporter
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#) A: Acquired
defect
G: Genetic defect
P: Predicted Pseudogene
L: like- or related-sequence
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