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SLC8:
The Na+/Ca2+ exchanger family
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Human Gene
Name
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Protein
Name
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Aliases
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Predominant Substrates
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Transport type /Coupling ions
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Tissue distribution and cellular/ subcellular expression
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Human gene locus
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Sequence
Accession
ID
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Splice variants and their specific features
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SLC8A1
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NCX1
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NACA
NCE
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Sodium, Calcium
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Exchanger/ Na+,Ca2+
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Ubiquitous tissue distribution.
Plasma membrane of various cell types.
In brain mainly in neurons and their dendrites.
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2p23-p22
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NM_021097
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Exon A splice variants in excitable tissues.
Exon B splice variants in all other tissues.
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SLC8A2
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NCX2
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Sodium, Calcium
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Exchanger/ Na+,Ca2+
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Predominantly in brain (glial cells) and skeletal
muscle.
Low transcript levels in various other tissues.
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19q13.3
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NM_015063
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No splice variants found.
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SLC8A3
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NCX3
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Sodium, Calcium
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Exchanger/ Na+,Ca2+
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Exclusively in brain (subpopulations of neuronal cells)
and skeletal muscle.
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14q24.1
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NM_033262
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Exon A splice variants in skeletal muscle.
Exon B splice variants in skeletal muscle and brain.
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