SLC5: The sodium glucose cotransporter family
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Human
Gene Name
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Protein Name
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Aliases
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Predominant
Substrates
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Transport type/Coupling ion*
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Tissues distribution and cellular/Subcellular
ExpressionT
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Link to disease
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Human gene locus
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Sequence Accession ID
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Splice variants and their specific features
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SLC5A1
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SGLT1
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None
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Glucose and Galactose (Urea and Water)
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C/ Na+ (H+)
F/ Na+ (H+)
Channel Urea and Water
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Small Intestine >>>> trachea, kidney and heart.
Plasma membranes.
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Glucose Glactose MalabsorptionG
OMIM 182380
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22q13.1
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NM_000343
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SLC5A2
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SGLT2
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None
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Glucose
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C/ Na+
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Kidney cortex
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Familial Renal GlucosuriaG
OMIM 182381
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16p12-p11
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NM_003041
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SLC5A3
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SMIT
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None
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Myoinositol (glucose)
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C/ Na+
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Brain, heart, kidney and lung. Plasma membranes.
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Down’s syndrome?
OMIM 600444
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21q22.12
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NM_006933
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Splicing within, and distal to Exon 2 leads to 3 transcripts (SMIT1, SMIT2 &
SMIT3). SMIT2 & 3 lack the 14th TMH.
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SLC5A4
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SGLT3
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SAAT1
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Na+ (H+)
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Glucose activated Na+ (H+) channel
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Small Intestine (Cholinergic neurons), skeletal muscle,
kidney, uterus and testis. Plasma membranes.
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22q12.2-q12.3
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NM_014227
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SLC5A5
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NIS
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I- (ClO4-, SCN-,
NO3-, Br-)
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C/Na+
Uniporter Na+
Channel Urea water
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Thyroid, breast, colon and ovary. Plasma membranes
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Thyroid hormonogenesisG
OMIM 601843
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19p13.2-p12
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NM_ 000453
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SLC5A6
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SMVT
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Biotin, lipoate and panthothenate
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C/Na+
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Brain, heart, kidney, lung and placenta. Plasma membranes.
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2p23
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NM
_021095
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SLC5A7
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CHT
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CHT1
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Choline
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C/Na+/Cl-
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Spinal cord and medulla (Intracellular vesicles).
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2q12
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NM
_021815
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SLC5A8
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SMCT1
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AIT
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short-chain fatty acids/lactate/nicotinate, iodide
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C/Na+
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Thyroid, apical plasma membrane, kidney, intestine
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12q23.1
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NM_145913
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SLC5A9**
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SGLT4
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mannose
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C/Na+
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Small Intestine, kidney. Liver, lung and brain.
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1p32
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NM_001011547
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Internal splice in Exon 14 adds either 38 or 53 aa between
TMHs 13 - 14.
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SLC5A10
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SGLT5
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Rabbit RK-D
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Kidney
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17p11.2
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NM_152351
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Exon 7 may be spliced out deleting 26 aa between TMHs 5-6;
internal splice in exon 10 means either 36 or 52 aa between
TMHs 8-9; and an internal splice in exon 12 adds either 12 or
37 aa between TMHs 11-12.
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| SLC5A11 |
SGLT6 |
KST1Rabbit ST1Rabbit SMIT2 |
Rabbit ortholog: Myoinositol, Chiro-inositol, glucose and
xylose.Xenopus laevis ortholog: Myoinositol and glucose. |
C/Na+ |
Small intestine, brain, kidney, liver, heart, and lung |
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16p12.1 |
NM_052944 |
Splicing eliminates Exon 6 and TMH 4. |
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SLC5A12
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SMCT2
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short-chain
fatty acids/lactate/nicotinate
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C/Na+
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kidney,
small intestine and skeletal muscle
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11p14.3
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NM_178498
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* C: Cotransporter;
F: uniporter. Function based on results obtained with heterologous
expression systems.
** Provisional SGLT4 exons identified by mining the Celera databases.
T: Tissue distribution of SGLT1-6 was determined by RNAase protection
assays using gene specific probes (Bing, M. Turk, E, Martin
MG & Wright, EM. In preparation). Also includes data from
the original cloning papers and GeneCard ( EST, and/or DNA array).
G: Gene defect.
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S: Potential alternative splice sites (56, 62 and Turk,
unpublished).
Original references may be obtained through the Accession Numbers
and/or the text. Note: SNPs and variants in the NCBI SNP Database
are not included.
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