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SLC4:
The bicarbonate transporter family
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|
Human
gene
name
|
Protein name
|
Aliases
|
Predominant substrates
|
Transport type*
|
Tissue distribution and cellular/subcellular expression
|
Link to
disease†
|
Human gene locus
|
Sequence
Accession
ID
|
Splice Variants and their
specific features
|
|
SLC4A1
|
AE1
|
Band 3
|
Chloride Bicarbonate
|
E
|
Erythrocytes, intercalated cells of renal collecting
duct, heart and colon
|
Hemolytic anemia, distal renal tubular acidosis
|
17q21–q22
|
NM_000342
|
2
|
| SLC4A1AP |
|
kanadaptin |
|
|
|
|
2p23.3 |
|
|
|
SLC4A2
|
AE2
|
|
Chloride Bicarbonate
|
E
|
Widely distributed; basolateral in most epithelial cells
|
|
7q35–36
|
NM_003040
|
5
|
|
SLC4A3
|
AE3
|
|
Chloride Bicarbonate
|
E
|
Brain, retina, heart and smooth muscle. Also epithelial
cells of kidney and GI tract
|
|
2q36
|
NM_005070
|
³ 2
|
|
SLC4A4
|
NBCe1
|
NBC,
NBC1
|
Sodium Bicarbonate (and/or Carbonate)
|
C
|
NBCe1-A: renal proximal tubule, eye
NBCe1-B: widely distributed, pancreas, heart, eye.
NBCe1-C: brain
|
Severe proximal renal tubular acidosis, ocular abnormalities,
short stature
|
4q21
|
NM_003759
|
|
|
SLC4A5
|
NBCe2
|
NBC4
|
Sodium Bicarbonate (and/or Carbonate)
|
C
|
Liver, Testes, Spleen
|
|
2p13
|
NM_133478
|
³ 1
|
|
SLC4A6
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
SLC4A7
|
NBCn1
|
NBC2,
NBC3
|
Sodium Bicarbonate
|
C
|
Widely distributed: spleen, testes,
brain, heart, lung, river.
|
Blindness, Auditory Impairment
|
3p22
|
NM_003615
|
³ 3
|
| SLC4A7OS |
|
bcm2841
|
|
|
|
|
3p24.1 |
|
|
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SLC4A8
|
NBCBE |
kNBC3 |
Sodium bicarbonate, chloride |
C and E |
Brain, testes, and ovary |
|
12q13 |
NM_004858
|
2 |
|
SLC4A9
|
- |
AE4 |
Inconclusive |
? |
At least kidney |
|
5q31 |
NM_031467
|
1 |
| SLC4A10 |
- |
NBCE |
Inconclusive |
? |
Brain |
|
2q23-q24 |
NM_022058
|
2 |
|
SLC4A11
|
NaBC1 |
BTR1 |
Borate (B(OH)4-), Na+, OH- |
C/Na+ |
Kidney, salivary gland, testis, thyroid, trachea
|
|
20p12 |
NM_032034
|
1 |
|
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