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SLC2: The facilitative GLUT transporter family |
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Human Gene Name |
Protein Name |
Aliases |
Predominant Substrates |
Transport type /Coupling ions *) |
Tissue distribution and cellular/ subcellular expression |
Link to disease #) |
Human gene locus |
Sequence Accession ID |
Splice variants and their specific features |
|
|
GLUT1 |
|
Glucose, Galactose, Mannose, glucosamine |
F |
Erythrocytes, brain, blood brain barrier, Blood-tissue barrier |
developmental delay, acquired microcephaly, hypotonia |
1p35-31.3 |
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GLUT2 |
|
Glucose, Galactose, Fructose, Mannose, glucosamine |
F |
Liver, islet of Langerhans, intestine, kidney, brain |
Fanconi-Bickel syndrome |
3q26.2-27 |
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GLUT3 |
|
Glucose, Galactose, Mannose, xylose |
F- |
Brain (neurons), testis |
|
12p13.3 |
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| SLC2A3P1 |
5q33-q35 |
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| SLC2A3P2 | 1p31.3 | AC025866 |
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| SLC2A3P3 | 12p13.3 |
AC006517 |
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| SLC2A3P4 | 8q21.3 |
AC103817 | ||||||||
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GLUT4 |
|
Glucose, glucosamine |
F |
Adipose tissue (white and brown), skeletal and cardiac muscle |
|
17p13 |
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| SLC2A4RG | GEF |
20 |
NM_020062 |
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GLUT5 |
|
Fructose |
F |
Small intestine, kidney |
|
1p36.2 |
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GLUT6 |
GLUT9 |
Glucose |
F |
Brain, spleen, leucocytes |
|
9q34 |
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GLUT7 |
|
O |
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1p36.2 |
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GLUT8 |
GLUTX1 |
Glucose, Fructose, Galactose |
F |
Testis, brain, adrenal gland, liver, spleen, brown adipose
tissue, lung |
|
9 |
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GLUT9 |
GLUTX |
O |
|
Kidney, liver, small intestine, placenta, lung and leucocytes |
|
4p15.3-16 |
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GLUT10 |
|
Glucose, Galactose |
F |
Heart, lung, brain, liver, skeletal muscle, pancreas, placenta
and kidney |
|
20q12-13.1 |
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GLUT11 |
GLUT10 |
Glucose, fructose |
F |
Heart, muscle |
|
22q11.2 |
3 splice variants |
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GLUT12 |
|
O |
|
Heart, prostate, skeletal muscle |
|
6q23.2 |
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HMIT |
GLUT13 |
Myo-inositol |
C |
Brain, adipose tissue |
|
12q11.23 |
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| SLC2A14 |
GLUT14 |
O |
Testis |
12p13.3 |
NM_153449 |
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*) |
#) |
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References: |