SLC2: The facilitative GLUT transporter family

Human Gene

Name

Protein

Name

Aliases

Predominant Substrates

Transport type /Coupling ions *)

Tissue distribution and cellular/ subcellular expression

 

Link to disease #)

Human gene locus

Sequence

Accession

ID

Splice variants and their specific features

SLC2A1

GLUT1

 

Glucose,

Galactose,

Mannose,

glucosamine

F

Erythrocytes, brain, blood brain barrier,

Blood-tissue barrier

developmental delay, acquired microcephaly, hypotonia

1p35-31.3

NM_006516

 

SLC2A2

GLUT2 

 

Glucose,

Galactose,

Fructose,

Mannose,

glucosamine

F

Liver, islet of Langerhans, intestine, kidney, brain

Fanconi-Bickel syndrome

3q26.2-27

NM_000340

 

SLC2A3

GLUT3

 

Glucose,

Galactose,

Mannose,

xylose

 

F-

Brain (neurons), testis

 

12p13.3

NM_006931

 

SLC2A3P1            

5q33-q35

 
SLC2A3P2             1p31.3 AC025866  
SLC2A3P3             12p13.3 AC006517  
SLC2A3P4             8q21.3 AC103817  

SLC2A4

GLUT4

 

Glucose,

glucosamine

F

Adipose tissue (white and brown), skeletal and cardiac muscle

 

17p13

NM_001042

 

SLC2A4RG GEF         20 NM_020062  

SLC2A5

GLUT5

 

Fructose

F

Small intestine, kidney

 

1p36.2

NM_003039

 

SLC2A6

GLUT6

GLUT9

Glucose

F

Brain, spleen, leucocytes

 

9q34

NM_017585

 

SLC2A7

GLUT7

 

O

 

 

 

1p36.2

 NM_207420

 

SLC2A8

GLUT8

GLUTX1

Glucose,

Fructose,

Galactose

 

F

Testis, brain, adrenal gland, liver, spleen, brown adipose tissue, lung

 

9q33.3

NM_014580

 

SLC2A9

GLUT9

GLUTX

O

 

Kidney, liver, small intestine, placenta, lung and leucocytes

 

4p15.3-16

NM_020041

 

SLC2A10

GLUT10

 

Glucose,

Galactose

F

Heart, lung, brain, liver, skeletal muscle, pancreas, placenta and kidney

 

20q12-13.1

NM_030777

 

SLC2A11

GLUT11

GLUT10

Glucose,

fructose

F

Heart, muscle

 

22q11.2

NM_030807

3 splice variants

SLC2A12

GLUT12

 

O

 

Heart, prostate, skeletal muscle

 

6q23.2

NM_145176

 

SLC2A13

 

HMIT

GLUT13

Myo-inositol

C

Brain, adipose tissue

 

12q11.23

NM_052885

 

SLC2A14 GLUT14     O Testis   12p13.3 NM_153449  

SLC2AXP1

 

 

 

2q11.2

AC026626

*)
C: Cotransporter
E: Exchanger
F: Facilitated transporter
O: Orphan transporter

#)
A: Acquired defect
G: Genetic defect
P: Pseudogene

 

References:

Original version of the SLC table:

Uldry M, Thorens B. The SLC2 family of facilitated hexose and polyol transporters. Pflugers Arch. 2004 Feb;447(5):480-9.