SLC1: The high affinity
glutamate and neutral amino acid transporter family
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Human Gene
Name
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Protein
Name
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Aliases
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Predominant Substrates
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Transport type /Coupling ions *)
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Tissue distribution and cellular/ subcellular expression
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Link to disease #)
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Human gene locus
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Sequence
Accession
ID
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Splice variants and their specific features
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SLC1A1
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EAAC1
EAAT3
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system X-AG
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L-Glu, D/L-Asp
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C/ Na+, H+ and K+
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Brain (neurons), intestine, kidney, liver, heart
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G/ Dicarboxylic amino
aciduria?
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9q24
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NM_004170
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SLC1A2
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GLT-1
EAAT2
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system X-AG
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L-Glu, D/L-Asp
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C/ Na+, H+ and K+
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Brain (astrocytes), liver
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A/ Amyotrophic lateral sclerosis
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11p13-p12
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NM_004171
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C-terminus spliced variants expressed in neurons
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SLC1A3
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GLAST EAAT1
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system X-AG
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L-Glu, D/L-Asp
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C/ Na+, H+ and K+
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Brain (astrocytes), heart, skeletal muscle, placenta
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5p13
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NM_004172
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SLC1A4
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ASCT1
SATT,
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system ASC
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L-Ala, L-Ser, L-Cys
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C/ Na+,
E/ amino acids
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Wide spread
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2p15-p13
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NM_003038
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SLC1A5
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ASCT2
AAAT
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system ASC
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L-Ala, L-Ser, L-Thr, L-Cys, L-Gln
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C/ Na+,
E/ amino acids
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Lung, skeletal muscle, large intestine, kidney, testis,
adipose tissue
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19q13.3
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NM_005628
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SLC1A6
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EAAT4
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system X-AG
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L-Glu, D/L-Asp
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C/ Na+, H+ and K+
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Cerebellum (Purkinje cells)
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19p13.12
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NM_005071
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SLC1A7
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EAAT5
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system X-AG
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L-Glu, D/L-Asp
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C/ Na+, H+ and K+
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Retina
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1p32.3
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NM_006671
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*)
C: Cotransporter
E: Exchanger
F: Facilitated transporter
O: Orphan transporter
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#)
A: Acquired defect
G: Genetic defect
P: Pseudogene
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